Literature DB >> 21079592

Grand challenge commentary: Beyond discovery: probes that see, grab and poke.

Joshua A Kritzer1.   

Abstract

Chemical biology is now able to discover molecules that manipulate virtually any biological target or process. It remains a grand challenge to leverage these molecules into useful probes that can be used to address unsolved problems in biology.

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Year:  2010        PMID： 21079592     DOI： 10.1038/nchembio.469

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  20 in total

Review 1.  Dimerizer-regulated gene expression.

Authors:  Roy Pollock; Tim Clackson
Journal:  Curr Opin Biotechnol       Date:  2002-10       Impact factor: 9.740

Review 2.  Target identification in chemical genetics: the (often) missing link.

Authors:  Lyle Burdine; Thomas Kodadek
Journal:  Chem Biol       Date:  2004-05

Review 3.  Chemical approaches for investigating phosphorylation in signal transduction networks.

Authors:  Deborah M Rothman; Melissa D Shults; Barbara Imperiali
Journal:  Trends Cell Biol       Date:  2005-09       Impact factor: 20.808

4.  Tagged small molecule library approach for facilitated chemical genetics.

Authors:  Young-Hoon Ahn; Young-Tae Chang
Journal:  Acc Chem Res       Date:  2007-06-05       Impact factor: 22.384

Review 5.  Cell-penetrating peptides as delivery vehicles for biology and medicine.

Authors:  Kelly M Stewart; Kristin L Horton; Shana O Kelley
Journal:  Org Biomol Chem       Date:  2008-04-15       Impact factor: 3.876

Review 6.  Activity-based protein profiling: from enzyme chemistry to proteomic chemistry.

Authors:  Benjamin F Cravatt; Aaron T Wright; John W Kozarich
Journal:  Annu Rev Biochem       Date:  2008       Impact factor: 23.643

Review 7.  Chemical inducers of targeted protein degradation.

Authors:  Kanak Raina; Craig M Crews
Journal:  J Biol Chem       Date:  2010-02-10       Impact factor: 5.157

8.  Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome.

Authors:  Heinz Neumann; Kaihang Wang; Lloyd Davis; Maria Garcia-Alai; Jason W Chin
Journal:  Nature       Date:  2010-02-14       Impact factor: 49.962

9.  Copper-free click chemistry in living animals.

Authors:  Pamela V Chang; Jennifer A Prescher; Ellen M Sletten; Jeremy M Baskin; Isaac A Miller; Nicholas J Agard; Anderson Lo; Carolyn R Bertozzi
Journal:  Proc Natl Acad Sci U S A       Date:  2010-01-14       Impact factor: 11.205

10.  Mammalian cell penetration, siRNA transfection, and DNA transfection by supercharged proteins.

Authors:  Brian R McNaughton; James J Cronican; David B Thompson; David R Liu
Journal:  Proc Natl Acad Sci U S A       Date:  2009-03-23       Impact factor: 11.205
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  3 in total

1.  Cardioproteomics: advancing the discovery of signaling mechanisms involved in cardiovascular diseases.

Authors:  Ziyou Cui; Shannamar Dewey; Aldrin V Gomes
Journal:  Am J Cardiovasc Dis       Date:  2011-09-10

2.  Peptide bicycles that inhibit the Grb2 SH2 domain.

Authors:  Justin S Quartararo; Pianpian Wu; Joshua A Kritzer
Journal:  Chembiochem       Date:  2012-06-11       Impact factor: 3.164

3.  proTeOn and proTeOff, new protein devices that inducibly activate bacterial gene expression.

Authors:  Katherine Volzing; Konstantinos Biliouris; Yiannis N Kaznessis
Journal:  ACS Chem Biol       Date:  2011-08-18       Impact factor: 5.100
  3 in total

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