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Literature DB >> 21079588

Grand challenge commentary: Transforming biosynthesis into an information science.

Abstract

Engineering biosynthetic pathways to natural products is a challenging endeavor that promises to provide new therapeutics and tools to manipulate biology. Information-guided design strategies and tools could unlock the creativity of a wide spectrum of scientists and engineers by decoupling expertise from implementation.

Mesh：

Substances：
Small Molecule Libraries

Year: 2010 PMID： 21079588 DOI： 10.1038/nchembio.487

Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040

13 in total

1. The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models.

Authors: M Hucka; A Finney; H M Sauro; H Bolouri; J C Doyle; H Kitano; A P Arkin; B J Bornstein; D Bray; A Cornish-Bowden; A A Cuellar; S Dronov; E D Gilles; M Ginkel; V Gor; I I Goryanin; W J Hedley; T C Hodgman; J-H Hofmeyr; P J Hunter; N S Juty; J L Kasberger; A Kremling; U Kummer; N Le Novère; L M Loew; D Lucio; P Mendes; E Minch; E D Mjolsness; Y Nakayama; M R Nelson; P F Nielsen; T Sakurada; J C Schaff; B E Shapiro; T S Shimizu; H D Spence; J Stelling; K Takahashi; M Tomita; J Wagner; J Wang
Journal: Bioinformatics Date: 2003-03-01 Impact factor: 6.937

Review 2. Polyketide and nonribosomal peptide antibiotics: modularity and versatility.

Authors: Christopher T Walsh
Journal: Science Date: 2004-03-19 Impact factor: 47.728

3. Biosynthesis: is it time to go retro?

Authors: Brian O Bachmann
Journal: Nat Chem Biol Date: 2010-06 Impact factor: 15.040

4. Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae.

Authors: Kristy M Hawkins; Christina D Smolke
Journal: Nat Chem Biol Date: 2008-09 Impact factor: 15.040

5. Production of the antimalarial drug precursor artemisinic acid in engineered yeast.

Authors: Dae-Kyun Ro; Eric M Paradise; Mario Ouellet; Karl J Fisher; Karyn L Newman; John M Ndungu; Kimberly A Ho; Rachel A Eachus; Timothy S Ham; James Kirby; Michelle C Y Chang; Sydnor T Withers; Yoichiro Shiba; Richmond Sarpong; Jay D Keasling
Journal: Nature Date: 2006-04-13 Impact factor: 49.962

Review 2. In vitro reconstitution guide for targeted synthetic metabolism of chemicals, nutraceuticals and drug precursors.

Authors: Gao-Yi Tan; Faying Zhu; Zixin Deng; Tiangang Liu
Journal: Synth Syst Biotechnol Date: 2016-04-01

2 in total

Grand challenge commentary: Transforming biosynthesis into an information science.

1. The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models.

Review 2. Polyketide and nonribosomal peptide antibiotics: modularity and versatility.

3. Biosynthesis: is it time to go retro?

4. Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae.

5. Production of the antimalarial drug precursor artemisinic acid in engineered yeast.

6. Metabolic engineering of Escherichia coli for the production of polylactic acid and its copolymers.

7. Enzymatic total synthesis of enterocin polyketides.

8. Gene Designer: a synthetic biology tool for constructing artificial DNA segments.

9. GenBank.

10. NCBI BLAST: a better web interface.

Review 1. Parts plus pipes: synthetic biology approaches to metabolic engineering.

Review 2. In vitro reconstitution guide for targeted synthetic metabolism of chemicals, nutraceuticals and drug precursors.