C Annweiler1, A M Schott, Y Rolland, H Blain, F R Herrmann, O Beauchet. 1. Department of Internal Medicine and Geriatrics, Angers University Hospital, Angers University Memory Center, UPRES EA 2646, University of Angers, UNAM, Angers, France. CeAnnweiler@chu-angers.fr
Abstract
BACKGROUND: Serum vitamin D concentrations are associated with global cognitive function among older adults. The benefits of vitamin D intake to treat or prevent cognitive impairment remain unknown. The objective of this cross-sectional study was to determine whether weekly dietary intake of vitamin D could be associated with global cognitive performance among older adults. METHODS: A total of 5,596 community-dwelling women (mean age 80.5 ± 0.1 years) free of vitamin D drug supplements from the Epidémiologie de l'Ostéoporose (EPIDOS) study were divided into 2 groups according to baseline weekly vitamin D dietary intake (either inadequate <35 μg/wk or recommended ≥35μg/wk). Weekly vitamin D dietary intakes were estimated from a self-administered food frequency questionnaire. Cognitive impairment was defined as a Pfeiffer Short Portable Mental State Questionnaire (SPMSQ) score <8. Age, body mass index, sun exposure at midday, season, disability, number of chronic diseases, hypertension, depression, use of psychoactive drugs, and education level were considered as potential confounders. RESULTS: Compared to women with recommended weekly vitamin D dietary intakes (n = 4,802; mean age 80.4 ± 3.8 years), women with inadequate intakes (n = 794; mean age 81.0 ± 3.8 years) had a lower mean SPMSQ score (p < 0.001) and more often had an SPMSQ score <8 (p = 0.002). We found an association between weekly vitamin D dietary intake and SPMSQ score (β = 0.002, p < 0.001). Inadequate weekly vitamin D dietary intakes were also associated with cognitive impairment (unadjusted odds ratio = 1.42 with p = 0.002; full adjusted odds ratio = 1.30 with p = 0.024). CONCLUSIONS: Weekly dietary intake of vitamin D was associated with cognitive performance in older women.
BACKGROUND: Serum vitamin D concentrations are associated with global cognitive function among older adults. The benefits of vitamin D intake to treat or prevent cognitive impairment remain unknown. The objective of this cross-sectional study was to determine whether weekly dietary intake of vitamin D could be associated with global cognitive performance among older adults. METHODS: A total of 5,596 community-dwelling women (mean age 80.5 ± 0.1 years) free of vitamin D drug supplements from the Epidémiologie de l'Ostéoporose (EPIDOS) study were divided into 2 groups according to baseline weekly vitamin D dietary intake (either inadequate <35 μg/wk or recommended ≥35μg/wk). Weekly vitamin D dietary intakes were estimated from a self-administered food frequency questionnaire. Cognitive impairment was defined as a Pfeiffer Short Portable Mental State Questionnaire (SPMSQ) score <8. Age, body mass index, sun exposure at midday, season, disability, number of chronic diseases, hypertension, depression, use of psychoactive drugs, and education level were considered as potential confounders. RESULTS: Compared to women with recommended weekly vitamin D dietary intakes (n = 4,802; mean age 80.4 ± 3.8 years), women with inadequate intakes (n = 794; mean age 81.0 ± 3.8 years) had a lower mean SPMSQ score (p < 0.001) and more often had an SPMSQ score <8 (p = 0.002). We found an association between weekly vitamin D dietary intake and SPMSQ score (β = 0.002, p < 0.001). Inadequate weekly vitamin D dietary intakes were also associated with cognitive impairment (unadjusted odds ratio = 1.42 with p = 0.002; full adjusted odds ratio = 1.30 with p = 0.024). CONCLUSIONS: Weekly dietary intake of vitamin D was associated with cognitive performance in older women.
Authors: May A Beydoun; Sharmin Hossain; Marie T Fanelli-Kuczmarski; Hind A Beydoun; Jose-Atilio Canas; Michele K Evans; Alan B Zonderman Journal: J Clin Endocrinol Metab Date: 2018-04-01 Impact factor: 5.958
Authors: May A Beydoun; Salman M Tajuddin; Greg A Dore; Jose-Atilio Canas; Hind A Beydoun; Michele K Evans; Alan B Zonderman Journal: J Nutr Date: 2017-04-26 Impact factor: 4.798
Authors: Y Rolland; P de Souto Barreto; G Abellan Van Kan; C Annweiler; O Beauchet; H Bischoff-Ferrari; G Berrut; H Blain; M Bonnefoy; M Cesari; G Duque; M Ferry; O Guerin; O Hanon; B Lesourd; J Morley; A Raynaud-Simon; G Ruault; J-C Souberbielle; B Vellas Journal: J Nutr Health Aging Date: 2013-04 Impact factor: 4.075