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Literature DB >> 21078124

GRAIL: a unique mediator of CD4 T-lymphocyte unresponsiveness.

Chan C Whiting¹, Leon L Su, Jack T Lin, C Garrison Fathman.

Abstract

GRAIL (gene related to anergy in lymphocytes, also known as RNF128), an ubiquitin-protein ligase (E3), utilizes a unique single transmembrane protein with a split-function motif, and is an important gatekeeper of T-cell unresponsiveness. Although it may play a role in other CD4 T-cell functions including activation, survival and differentiation, GRAIL is most well characterized as a negative regulator of T-cell receptor responsiveness and cytokine production. Here, we review the recent literature on this remarkable E3 in the regulation of human and mouse CD4 T-cell unresponsiveness.

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Year: 2010 PMID： 21078124 PMCID： PMC3058357 DOI： 10.1111/j.1742-4658.2010.07922.x

Source DB: PubMed Journal: FEBS J ISSN： 1742-464X Impact factor: 5.542

64 in total

1. GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells.

Authors: Niroshana Anandasabapathy; Gregory S Ford; Debra Bloom; Claire Holness; Violette Paragas; Christine Seroogy; Heidi Skrenta; Marie Hollenhorst; C Garrison Fathman; Luis Soares
Journal: Immunity Date: 2003-04 Impact factor: 31.745

Review 2. E3 ubiquitin ligases as T cell anergy factors.

Authors: Daniel L Mueller
Journal: Nat Immunol Date: 2004-09 Impact factor: 25.606

3. Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins.

Authors: Vigo Heissmeyer; Fernando Macián; Sin-Hyeog Im; Rajat Varma; Stefan Feske; K Venuprasad; Hua Gu; Yun-Cai Liu; Michael L Dustin; Anjana Rao
Journal: Nat Immunol Date: 2004-02-15 Impact factor: 25.606

4. The majority of CD4+8- thymocytes are functionally immature.

Authors: F Ramsdell; M Jenkins; Q Dinh; B J Fowlkes
Journal: J Immunol Date: 1991-09-15 Impact factor: 5.422

5. Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness.

Authors: H Quill; R H Schwartz
Journal: J Immunol Date: 1987-06-01 Impact factor: 5.422

6. Two isoforms of otubain 1 regulate T cell anergy via GRAIL.

Authors: Luis Soares; Christine Seroogy; Heidi Skrenta; Niroshana Anandasabapathy; Patricia Lovelace; Chan D Chung; Edgar Engleman; C Garrison Fathman
Journal: Nat Immunol Date: 2003-12-07 Impact factor: 25.606

7. Murine CD4+CD25+ regulatory T cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene.

Authors: Leon Su; Remi J Creusot; Elena M Gallo; Steven M Chan; Paul J Utz; C Garrison Fathman; Joerg Ermann
Journal: J Immunol Date: 2004-10-15 Impact factor: 5.422

8. Anergic T-lymphocyte clones have altered inositol phosphate, calcium, and tyrosine kinase signaling pathways.

Authors: T F Gajewski; D Qian; P Fields; F W Fitch
Journal: Proc Natl Acad Sci U S A Date: 1994-01-04 Impact factor: 11.205

9. The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells.

Authors: Christine M Seroogy; Luis Soares; Erik A Ranheim; Leon Su; Claire Holness; Debra Bloom; C Garrison Fathman
Journal: J Immunol Date: 2004-07-01 Impact factor: 5.422

10. CD151 regulates epithelial cell-cell adhesion through PKC- and Cdc42-dependent actin cytoskeletal reorganization.

Authors: Masaki Shigeta; Noriko Sanzen; Masayuki Ozawa; Jianguo Gu; Hitoshi Hasegawa; Kiyotoshi Sekiguchi
Journal: J Cell Biol Date: 2003-10-13 Impact factor: 10.539

18 in total

1. Grail as a molecular determinant for the functions of the tumor suppressor p53 in tumorigenesis.

Authors: Y-C Chen; J Y-H Chan; Y-L Chiu; S-T Liu; G Lozano; S-L Wang; C-L Ho; S-M Huang
Journal: Cell Death Differ Date: 2013-02-01 Impact factor: 15.828

Review 2. Regulation of T cell receptor complex-mediated signaling by ubiquitin and ubiquitin-like modifications.

Authors: Samantha F Friend; Francina Deason-Towne; Lisa K Peterson; Allison J Berger; Leonard L Dragone
Journal: Am J Clin Exp Immunol Date: 2014-12-05

3. Regulation of anergy-related ubiquitin E3 ligase, GRAIL, in murine models of colitis and patients with Crohn's disease.

Authors: Akira Mukai; Hideki Iijima; Satoshi Hiyama; Hironobu Fujii; Shinichiro Shinzaki; Takahiro Inoue; Eri Shiraishi; Shoichiro Kawai; Manabu Araki; Yoshito Hayashi; Jumpei Kondo; Tsunekazu Mizushima; Tatsuya Kanto; Satoshi Egawa; Tsutomu Nishida; Masahiko Tsujii; Tetsuo Takehara
Journal: J Gastroenterol Date: 2013-12-20 Impact factor: 7.527

GRAIL: a unique mediator of CD4 T-lymphocyte unresponsiveness.

1. GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells.

Review 2. E3 ubiquitin ligases as T cell anergy factors.

3. Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins.

4. The majority of CD4+8- thymocytes are functionally immature.

5. Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness.

6. Two isoforms of otubain 1 regulate T cell anergy via GRAIL.

7. Murine CD4+CD25+ regulatory T cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene.

8. Anergic T-lymphocyte clones have altered inositol phosphate, calcium, and tyrosine kinase signaling pathways.

9. The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells.

10. CD151 regulates epithelial cell-cell adhesion through PKC- and Cdc42-dependent actin cytoskeletal reorganization.

1. Grail as a molecular determinant for the functions of the tumor suppressor p53 in tumorigenesis.

Review 2. Regulation of T cell receptor complex-mediated signaling by ubiquitin and ubiquitin-like modifications.

3. Regulation of anergy-related ubiquitin E3 ligase, GRAIL, in murine models of colitis and patients with Crohn's disease.

Review 4. Rethinking peripheral T cell tolerance: checkpoints across a T cell's journey.

5. Global Analysis of O-GlcNAc Glycoproteins in Activated Human T Cells.

6. Upregulation of GRAIL is associated with impaired CD4 T cell proliferation in sepsis.

7. The structural basis of R-spondin recognition by LGR5 and RNF43.

8. Mannose-Capped Lipoarabinomannan from Mycobacterium tuberculosis Induces CD4+ T Cell Anergy via GRAIL.

Review 9. Immune synapse: conductor of orchestrated organelle movement.

10. The Role of the Transmembrane RING Finger Proteins in Cellular and Organelle Function.