| Literature DB >> 21075633 |
Pradip K Sasmal1, D Srinivasa Reddy, Rashmi Talwar, B Venkatesham, D Balasubrahmanyam, M Kannan, P Srinivas, K Shiva Kumar, B Neelima Devi, Vikram P Jadhav, Sanjoy K Khan, Priya Mohan, Hira Chaudhury, Debnath Bhuniya, Javed Iqbal, Ranjan Chakrabarti.
Abstract
The synthesis and biological evaluation of novel pyrazole-3-carboxamide derivatives as CB1 antagonists are described. As a part of eastern amide SAR, various chemically diverse motifs were introduced. In general, a range of modifications were well tolerated. Several molecules with high polar surface area were also identified as potent CB1 receptor antagonists. The in vivo proof of principle for weight loss is exemplified with a lead compound from this series.Entities:
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Year: 2010 PMID： 21075633 DOI： 10.1016/j.bmcl.2010.10.055
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823