Literature DB >> 21075350

Anthrax toxin delivers a one-two punch.

Kenneth A Bradley1, Steven M LeVine.   

Abstract

Although anthrax toxin was identified as a major Bacillus anthracis virulence factor over 50 years ago, defining the physiologically relevant targets has been challenging. Liu et al. demonstrate that intoxication of myeloid-derived cells contributes to establishing infection but is not required for mortality resulting from high toxin concentrations associated with end-stage disease.
Copyright © 2010 Elsevier Inc. All rights reserved.

Entities:  

Year:  2010        PMID： 21075350      PMCID： PMC3031175          DOI： 10.1016/j.chom.2010.10.011

Source DB:  PubMed          Journal:  Cell Host Microbe        ISSN： 1931-3128            Impact factor:   21.023


  10 in total

1.  Anthrax toxin targeting of myeloid cells through the CMG2 receptor is essential for establishment of Bacillus anthracis infections in mice.

Authors:  Shihui Liu; Sharmina Miller-Randolph; Devorah Crown; Mahtab Moayeri; Inka Sastalla; Shu Okugawa; Stephen H Leppla
Journal:  Cell Host Microbe       Date:  2010-11-18       Impact factor: 21.023

2.  Roles of macrophages and neutrophils in the early host response to Bacillus anthracis spores in a mouse model of infection.

Authors:  Christopher K Cote; Nico Van Rooijen; Susan L Welkos
Journal:  Infect Immun       Date:  2006-01       Impact factor: 3.441

3.  Anthrax toxin receptor 2 mediates Bacillus anthracis killing of macrophages following spore challenge.

Authors:  David J Banks; Moshe Barnajian; Francisco J Maldonado-Arocho; Ana M Sanchez; Kenneth A Bradley
Journal:  Cell Microbiol       Date:  2005-08       Impact factor: 3.715

4.  Toxin-deficient mutants of Bacillus anthracis are lethal in a murine model for pulmonary anthrax.

Authors:  Sara Heninger; Melissa Drysdale; Julie Lovchik; Julie Hutt; Mary F Lipscomb; Theresa M Koehler; C Rick Lyons
Journal:  Infect Immun       Date:  2006-08-21       Impact factor: 3.441

5.  Cutting edge: resistance to Bacillus anthracis infection mediated by a lethal toxin sensitive allele of Nalp1b/Nlrp1b.

Authors:  Jill K Terra; Christopher K Cote; Bryan France; Amy L Jenkins; Joel A Bozue; Susan L Welkos; Steven M LeVine; Kenneth A Bradley
Journal:  J Immunol       Date:  2009-11-30       Impact factor: 5.422

Review 6.  Cellular and systemic effects of anthrax lethal toxin and edema toxin.

Authors:  Mahtab Moayeri; Stephen H Leppla
Journal:  Mol Aspects Med       Date:  2009-07-26

7.  Early interactions between fully virulent Bacillus anthracis and macrophages that influence the balance between spore clearance and development of a lethal infection.

Authors:  Christopher K Cote; Tracy L DiMezzo; David J Banks; Bryan France; Kenneth A Bradley; Susan L Welkos
Journal:  Microbes Infect       Date:  2008-02-21       Impact factor: 2.700

8.  Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process.

Authors:  A M Friedlander
Journal:  J Biol Chem       Date:  1986-06-05       Impact factor: 5.157

9.  Effects of anthrax toxin components on human neutrophils.

Authors:  J O'Brien; A Friedlander; T Dreier; J Ezzell; S Leppla
Journal:  Infect Immun       Date:  1985-01       Impact factor: 3.441

10.  Observations on experimental anthrax; demonstration of a specific lethal factor produced in vivo by Bacillus anthracis.

Authors:  H SMITH; J KEPPIE
Journal:  Nature       Date:  1954-05-08       Impact factor: 49.962
  10 in total
  3 in total

1.  Anthrax lethal toxin-induced lung injury and treatment by activating MK2.

Authors:  Tiegang Liu; Rod R Warburton; Nicholas S Hill; Usamah S Kayyali
Journal:  J Appl Physiol (1985)       Date:  2015-06-11

2.  Anthrax lethal toxin disrupts the endothelial permeability barrier through blocking p38 signaling.

Authors:  Tiegang Liu; Erica Milia; Rod R Warburton; Nicholas S Hill; Matthias Gaestel; Usamah S Kayyali
Journal:  J Cell Physiol       Date:  2012-04       Impact factor: 6.384

3.  Rapid vascular responses to anthrax lethal toxin in mice containing a segment of chromosome 11 from the CAST/Ei strain on a C57BL/6 genetic background.

Authors:  Kelsey J Weigel; Laura Rues; Edward J Doyle; Cassandra L Buchheit; John G Wood; Ryan J Gallagher; Laura E Kelly; Jeffrey D Radel; Kenneth A Bradley; Steven M LeVine
Journal:  PLoS One       Date:  2012-07-05       Impact factor: 3.240
  3 in total

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