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Literature DB >> 21075306

An identity crisis for a cancer gene: subcellular location determines ASPP1 function.

James J Manfredi¹.

Abstract

Entities: Chemical Disease Gene Species

Year: 2010 PMID： 21075306 PMCID： PMC3001292 DOI： 10.1016/j.ccr.2010.11.003

Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743

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9 in total

1. ASPP proteins specifically stimulate the apoptotic function of p53.

Authors: Y Samuels-Lev; D J O'Connor; D Bergamaschi; G Trigiante; J K Hsieh; S Zhong; I Campargue; L Naumovski; T Crook; X Lu
Journal: Mol Cell Date: 2001-10 Impact factor: 17.970

2. The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1.

Authors: Yael Aylon; Yaara Ofir-Rosenfeld; Norikazu Yabuta; Eleonora Lapi; Hiroshi Nojima; Xin Lu; Moshe Oren
Journal: Genes Dev Date: 2010-11-01 Impact factor: 11.361

3. Cytoplasmic ASPP1 inhibits apoptosis through the control of YAP.

Authors: Arnaud M Vigneron; Robert L Ludwig; Karen H Vousden
Journal: Genes Dev Date: 2010-11-01 Impact factor: 11.361

4. A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization.

Authors: Yael Aylon; Dan Michael; Ayelet Shmueli; Norikazu Yabuta; Hiroshi Nojima; Moshe Oren
Journal: Genes Dev Date: 2006-10-01 Impact factor: 11.361

5. The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA Damage.

Authors: Sabrina Strano; Olimpia Monti; Natalia Pediconi; Alessia Baccarini; Giulia Fontemaggi; Eleonora Lapi; Fiamma Mantovani; Alexander Damalas; Gennaro Citro; Ada Sacchi; Giannino Del Sal; Massimo Levrero; Giovanni Blandino
Journal: Mol Cell Date: 2005-05-13 Impact factor: 17.970

An identity crisis for a cancer gene: subcellular location determines ASPP1 function.

1. ASPP proteins specifically stimulate the apoptotic function of p53.

2. The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1.

3. Cytoplasmic ASPP1 inhibits apoptosis through the control of YAP.

4. A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization.

5. The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA Damage.

6. TEAD mediates YAP-dependent gene induction and growth control.

Review 7. YAP: at the crossroad between transformation and tumor suppression.

Review 8. Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling.

Review 9. ASPP: a new family of oncogenes and tumour suppressor genes.