Literature DB >> 21074044

Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues.

Jacob H Hanna1, Krishanu Saha, Rudolf Jaenisch.   

Abstract

Direct reprogramming of somatic cells to induced pluripotent stem cells by ectopic expression of defined transcription factors has raised fundamental questions regarding the epigenetic stability of the differentiated cell state. In addition, evidence has accumulated that distinct states of pluripotency can interconvert through the modulation of both cell-intrinsic and exogenous factors. To fully realize the potential of in vitro reprogrammed cells, we need to understand the molecular and epigenetic determinants that convert one cell type into another. Here we review recent advances in this rapidly moving field and emphasize unresolved and controversial questions.
Copyright © 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 21074044      PMCID： PMC3032267          DOI： 10.1016/j.cell.2010.10.008

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  99 in total

1.  Lab-specific gene expression signatures in pluripotent stem cells.

Authors:  Aaron M Newman; James B Cooper
Journal:  Cell Stem Cell       Date:  2010-08-06       Impact factor: 24.633

2.  Generation of induced pluripotent stem cells from human terminally differentiated circulating T cells.

Authors:  Tomohisa Seki; Shinsuke Yuasa; Mayumi Oda; Toru Egashira; Kojiro Yae; Dai Kusumoto; Hikari Nakata; Shugo Tohyama; Hisayuki Hashimoto; Masaki Kodaira; Yohei Okada; Hiroyuki Seimiya; Noemi Fusaki; Mamoru Hasegawa; Keiichi Fukuda
Journal:  Cell Stem Cell       Date:  2010-07-02       Impact factor: 24.633

3.  Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming.

Authors:  Payman Samavarchi-Tehrani; Azadeh Golipour; Laurent David; Hoon-Ki Sung; Tobias A Beyer; Alessandro Datti; Knut Woltjen; Andras Nagy; Jeffrey L Wrana
Journal:  Cell Stem Cell       Date:  2010-06-17       Impact factor: 24.633

4.  Reprogramming of human peripheral blood cells to induced pluripotent stem cells.

Authors:  Judith Staerk; Meelad M Dawlaty; Qing Gao; Dorothea Maetzel; Jacob Hanna; Cesar A Sommer; Gustavo Mostoslavsky; Rudolf Jaenisch
Journal:  Cell Stem Cell       Date:  2010-07-02       Impact factor: 24.633

5.  Reprogramming of T cells from human peripheral blood.

Authors:  Yuin-Han Loh; Odelya Hartung; Hu Li; Chunguang Guo; Julie M Sahalie; Philip D Manos; Achia Urbach; Garrett C Heffner; Marica Grskovic; Francois Vigneault; M William Lensch; In-Hyun Park; Suneet Agarwal; George M Church; James J Collins; Stefan Irion; George Q Daley
Journal:  Cell Stem Cell       Date:  2010-07-02       Impact factor: 24.633

6.  Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells.

Authors:  Matthew G Guenther; Garrett M Frampton; Frank Soldner; Dirk Hockemeyer; Maya Mitalipova; Rudolf Jaenisch; Richard A Young
Journal:  Cell Stem Cell       Date:  2010-08-06       Impact factor: 24.633

7.  Human adult germline stem cells in question.

Authors:  Kinarm Ko; Marcos J Araúzo-Bravo; Natalia Tapia; Julee Kim; Qiong Lin; Christof Bernemann; Dong Wook Han; Luca Gentile; Peter Reinhardt; Boris Greber; Rebekka K Schneider; Sabine Kliesch; Martin Zenke; Hans R Schöler
Journal:  Nature       Date:  2010-06-24       Impact factor: 49.962

8.  A murine ESC-like state facilitates transgenesis and homologous recombination in human pluripotent stem cells.

Authors:  Christa Buecker; Hsu-Hsin Chen; Jose Maria Polo; Laurence Daheron; Lei Bu; Tahsin Stefan Barakat; Patricia Okwieka; Andrew Porter; Joost Gribnau; Konrad Hochedlinger; Niels Geijsen
Journal:  Cell Stem Cell       Date:  2010-06-04       Impact factor: 24.633

9.  Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors.

Authors:  Masaki Ieda; Ji-Dong Fu; Paul Delgado-Olguin; Vasanth Vedantham; Yohei Hayashi; Benoit G Bruneau; Deepak Srivastava
Journal:  Cell       Date:  2010-08-06       Impact factor: 41.582

10.  Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway.

Authors:  Petra Hajkova; Sean J Jeffries; Caroline Lee; Nigel Miller; Stephen P Jackson; M Azim Surani
Journal:  Science       Date:  2010-07-02       Impact factor: 47.728
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  290 in total

Review 1.  Impact of induced pluripotent stem cells on the study of central nervous system disease.

Authors:  Paige E Cundiff; Stewart A Anderson
Journal:  Curr Opin Genet Dev       Date:  2011-01-27       Impact factor: 5.578

Review 2.  Mechanism and methods to induce pluripotency.

Authors:  Peizhe Wang; Jie Na
Journal:  Protein Cell       Date:  2011-11-06       Impact factor: 14.870

3.  Two-factor reprogramming of somatic cells to pluripotent stem cells reveals partial functional redundancy of Sox2 and Klf4.

Authors:  A Nemajerova; S Y Kim; O Petrenko; U M Moll
Journal:  Cell Death Differ       Date:  2012-04-27       Impact factor: 15.828

4.  Humanized murine model for HBV and HCV using human induced pluripotent stem cells.

Authors:  Xiao-Ling Zhou; Gareth J Sullivan; Pingnan Sun; In-Hyun Park
Journal:  Arch Pharm Res       Date:  2012-02-28       Impact factor: 4.946

Review 5.  Redefining Parkinson's disease research using induced pluripotent stem cells.

Authors:  Jiali Pu; Houbo Jiang; Baorong Zhang; Jian Feng
Journal:  Curr Neurol Neurosci Rep       Date:  2012-08       Impact factor: 5.081

6.  Converting scar to muscle in the injured heart.

Authors:  Paul R Riley
Journal:  Mol Ther       Date:  2012-07       Impact factor: 11.454

Review 7.  Learning the molecular mechanisms of the reprogramming factors: let's start from microRNAs.

Authors:  Chao-Shun Yang; Tariq M Rana
Journal:  Mol Biosyst       Date:  2012-10-05

8.  SMAD7 directly converts human embryonic stem cells to telencephalic fate by a default mechanism.

Authors:  Mohammad Zeeshan Ozair; Scott Noggle; Aryeh Warmflash; Joanna Ela Krzyspiak; Ali H Brivanlou
Journal:  Stem Cells       Date:  2013-01       Impact factor: 6.277

9.  Modified lentiviral LTRs allow Flp recombinase-mediated cassette exchange and in vivo tracing of "factor-free" induced pluripotent stem cells.

Authors:  Johannes Kuehle; Soeren Turan; Tobias Cantz; Dirk Hoffmann; Julia D Suerth; Tobias Maetzig; Daniela Zychlinski; Christoph Klein; Doris Steinemann; Christopher Baum; Juergen Bode; Axel Schambach
Journal:  Mol Ther       Date:  2014-01-17       Impact factor: 11.454

10.  Deterministic direct reprogramming of somatic cells to pluripotency.

Authors:  Yoach Rais; Asaf Zviran; Shay Geula; Ohad Gafni; Elad Chomsky; Sergey Viukov; Abed AlFatah Mansour; Inbal Caspi; Vladislav Krupalnik; Mirie Zerbib; Itay Maza; Nofar Mor; Dror Baran; Leehee Weinberger; Diego A Jaitin; David Lara-Astiaso; Ronnie Blecher-Gonen; Zohar Shipony; Zohar Mukamel; Tzachi Hagai; Shlomit Gilad; Daniela Amann-Zalcenstein; Amos Tanay; Ido Amit; Noa Novershtern; Jacob H Hanna
Journal:  Nature       Date:  2013-09-18       Impact factor: 49.962
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