| Literature DB >> 21072335 |
Jia Liu1, Chung-Hang Leung, Andy Lok-Fung Chow, Raymond Wai-Yin Sun, Siu-Cheong Yan, Chi-Ming Che.
Abstract
A platinum(II)-based major groove binder [Pt(II)(C^N)(C≡NR)(2)](+) (HC^N = 2-phenylpyridine (phpy), R = 2-naphthyl) was identified as a potent human topoisomerase IIα poison. It stabilizes the covalent TopoIIα-DNA cleavage complex and induces cancer cell death with potency significantly higher than the widely clinically used TopoIIα poison Vp-16.Entities:
Mesh：
Substances：
Year: 2010 PMID： 21072335 DOI： 10.1039/c0cc03641b
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222