Literature DB >> 21071221

Synthesis and in vitro evaluation of novel coumarin-chalcone hybrids as potential anticancer agents.

Koneni V Sashidhara1, Abdhesh Kumar, Manoj Kumar, Jayanta Sarkar, Sudhir Sinha.   

Abstract

A series of coumarin-chalcone hybrids have been synthesized and evaluated for their in vitro cytotoxicity against a panel of four human cancer cell lines and normal fibroblasts (NIH3T3). Among 21 compounds screened, three compounds (23, 25 and 26) showed IC(50) range from 3.59 to 8.12 μM. The most promising compound 26 showed around 30-fold more selectivity towards C33A (cervical carcinoma) cells over normal fibroblast NIH3T3 cells with an IC(50) value of 3.59 μM.
Copyright © 2010 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 21071221     DOI： 10.1016/j.bmcl.2010.10.116

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  28 in total

1.  An orally antitumor chalcone hybrid inhibited HepG2 cells growth and migration as the tubulin binding agent.

Authors:  Wang Yan; Chen Xiangyu; Li Ya; Wang Yu; Xu Feng
Journal:  Invest New Drugs       Date:  2019-02-11       Impact factor: 3.850

2.  Synthesis, docking and anticancer activity of azo-linked hybrids of 1,3,4-thia-/oxadiazoles with cyclic imides.

Authors:  Priyanka Bhatt; Manoj Kumar; Anjali Jha
Journal:  Mol Divers       Date:  2018-06-08       Impact factor: 2.943

Review 3.  Are Antimalarial Hybrid Molecules a Close Reality or a Distant Dream?

Authors:  Drishti Agarwal; Rinkoo D Gupta; Satish K Awasthi
Journal:  Antimicrob Agents Chemother       Date:  2017-04-24       Impact factor: 5.191

4.  Bergapten induces ER depletion in breast cancer cells through SMAD4-mediated ubiquitination.

Authors:  M L Panno; F Giordano; P Rizza; M Pellegrino; D Zito; C Giordano; L Mauro; S Catalano; S Aquila; D Sisci; F De Amicis; A Vivacqua; S W A Fuqua; S Andò
Journal:  Breast Cancer Res Treat       Date:  2012-10-09       Impact factor: 4.872

Review 5.  Chalcone: A Privileged Structure in Medicinal Chemistry.

Authors:  Chunlin Zhuang; Wen Zhang; Chunquan Sheng; Wannian Zhang; Chengguo Xing; Zhenyuan Miao
Journal:  Chem Rev       Date:  2017-05-10       Impact factor: 60.622

6.  Combinatorial Synthesis of Structurally Diverse Triazole-Bridged Flavonoid Dimers and Trimers.

Authors:  Tze Han Sum; Tze Jing Sum; Warren R J D Galloway; Súil Collins; David G Twigg; Florian Hollfelder; David R Spring
Journal:  Molecules       Date:  2016-09-16       Impact factor: 4.411

7.  Novel Coumarin Substituted Water Soluble Cyclophosphazenes as "Turn-Off" Type Fluorescence Chemosensors for Detection of Fe(3+) ions in Aqueous Media.

Authors:  Gönül Yenilmez Çiftçi; Elif Şenkuytu; Mustafa Bulut; Mahmut Durmuş
Journal:  J Fluoresc       Date:  2015-09-29       Impact factor: 2.217

8.  Dual Fluorescence and Solvatochromic Study on 3-Acyl Coumarins.

Authors:  S Samundeeswari; M V Kulkarni; Jayashree Yenagi; J Tonannavar
Journal:  J Fluoresc       Date:  2017-04-03       Impact factor: 2.217

9.  Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus.

Authors:  Koneni V Sashidhara; K Bhaskara Rao; Pragati Kushwaha; Ram K Modukuri; Pratiksha Singh; Isha Soni; P K Shukla; Sidharth Chopra; Mukesh Pasupuleti
Journal:  ACS Med Chem Lett       Date:  2015-05-29       Impact factor: 4.345

10.  Benzylidenetetralones, cyclic chalcone analogues, induce cell cycle arrest and apoptosis in HCT116 colorectal cancer cells.

Authors:  David Drutovic; Martina Chripkova; Martina Pilatova; Peter Kruzliak; Pal Perjesi; Marek Sarissky; Monica Lupi; Giovanna Damia; Massimo Broggini; Jan Mojzis
Journal:  Tumour Biol       Date:  2014-07-10
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.