| Literature DB >> 2107026 |
N J MacDonald1, D Kuhl, D Maguire, D Näf, P Gallant, A Goswamy, H Hug, H Büeler, M Chaturvedi, J de la Fuente, H Ruffner, F Meyer, C Weissman.
Abstract
Multimerization of GAAANN generates sequences frequent in virus-inducible promoters. We distinguished different types of (GAAANN)4 sequences mediating virus inducibility. Type I (NN = GT, GC, CT, or CC) responds to IFNs and to IRF-1 and causes silencing. Type II (NN = TG) and type III (NN = CG) neither silence nor respond to IRF-1 or IFN. Type III mediates constitutive transcription and binds the constitutive IEFga factor, whereas type II binds the novel "TG protein". IFN-beta and IFN-alpha 1 promoters contain different response elements: The former has a type I-like sequence (PRDI) and an NF-kappa B-binding sequence (PRDII); the latter has a type II-like "TG sequence" and possibly additional elements but does not bind NF-kappa B. Type I, type II, and NF-kappa B elements represent three distinct terminal pathways mediating virus induction.Entities:
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Year: 1990 PMID： 2107026 DOI： 10.1016/0092-8674(90)90091-r
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582