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Literature DB >> 1705037

Multimerization of AAGTGA and GAAAGT generates sequences that mediate virus inducibility by mimicking an interferon promoter element.

Abstract

Multimeric AAGTGA and GAAAGT, when inserted before a minimal promoter, mediate virus-inducible transcription. We have determined that the active sequence within these multimers is TGAAAGTGAAAGT, which is structurally similar to GAGAAGTGAAAGT, a positive response element delineated in the beta-interferon gene promoter. Both sequences behave like protoenhancers and are similar as regards induction by virus or interferon regulatory factor 1 when supported by a simian virus 40 enhancer.

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Year: 1991 PMID： 1705037 PMCID： PMC51019 DOI： 10.1073/pnas.88.4.1369

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

31 in total

1. Absence of the type I IFN system in EC cells: transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated.

Authors: H Harada; K Willison; J Sakakibara; M Miyamoto; T Fujita; T Taniguchi
Journal: Cell Date: 1990-10-19 Impact factor: 41.582

2. Different pathways mediate virus inducibility of the human IFN-alpha 1 and IFN-beta genes.

Authors: N J MacDonald; D Kuhl; D Maguire; D Näf; P Gallant; A Goswamy; H Hug; H Büeler; M Chaturvedi; J de la Fuente; H Ruffner; F Meyer; C Weissman
Journal: Cell Date: 1990-03-09 Impact factor: 41.582

3. A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence.

Authors: C M Fan; T Maniatis
Journal: Genes Dev Date: 1990-01 Impact factor: 11.361

4. An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes.

Authors: P H Driggers; D L Ennist; S L Gleason; W H Mak; M S Marks; B Z Levi; J R Flanagan; E Appella; K Ozato
Journal: Proc Natl Acad Sci U S A Date: 1990-05 Impact factor: 11.205

5. Induction of endogenous IFN-alpha and IFN-beta genes by a regulatory transcription factor, IRF-1.

Authors: T Fujita; Y Kimura; M Miyamoto; E L Barsoumian; T Taniguchi
Journal: Nature Date: 1989-01-19 Impact factor: 49.962

6. The human beta-interferon gene enhancer is under negative control.

Authors: S Goodbourn; H Burstein; T Maniatis
Journal: Cell Date: 1986-05-23 Impact factor: 41.582

7. The separation and identification of alpha- and beta-globin messenger ribonucleic acids.

Authors: M R Morrison; S A Brinkley; J Gorski; J B Lingrel
Journal: J Biol Chem Date: 1974-08-25 Impact factor: 5.157

8. Multiple protein-DNA interactions within the human interferon-beta regulatory element.

Authors: S Xanthoudakis; L Cohen; J Hiscott
Journal: J Biol Chem Date: 1989-01-15 Impact factor: 5.157

9. Not more than 117 base pairs of 5'-flanking sequence are required for inducible expression of a human IFN-alpha gene.

Authors: H Ragg; C Weissmann
Journal: Nature Date: 1983 Jun 2-8 Impact factor: 49.962

10. Synergism between distinct enhanson domains in viral induction of the human beta interferon gene.

Authors: J F Leblanc; L Cohen; M Rodrigues; J Hiscott
Journal: Mol Cell Biol Date: 1990-08 Impact factor: 4.272

17 in total

1. Transformation of a novel direct-repeat repressor element into a promoter and enhancer by multimerisation.

Authors: K C Chang; E Hansen; T Jaenicke; G Goldspink; P Butterworth
Journal: Nucleic Acids Res Date: 1992-04-11 Impact factor: 16.971

2. Identification of novel factors that bind to the PRD I region of the human beta-interferon promoter.

Authors: S T Whiteside; K V Visvanathan; S Goodbourn
Journal: Nucleic Acids Res Date: 1992-04-11 Impact factor: 16.971

3. A novel PRD I and TG binding activity involved in virus-induced transcription of IFN-A genes.

Authors: P Génin; J Bragança; N Darracq; J Doly; A Civas
Journal: Nucleic Acids Res Date: 1995-12-25 Impact factor: 16.971

4. NF-kappa B-independent activation of beta-interferon expression in mouse F9 embryonal carcinoma cells.

Authors: M J Ellis; S Goodbourn
Journal: Nucleic Acids Res Date: 1994-10-25 Impact factor: 16.971

5. Genome-wide analysis of interferon regulatory factor I binding in primary human monocytes.

Authors: Lihua Shi; Juan C Perin; Jeremy Leipzig; Zhe Zhang; Kathleen E Sullivan
Journal: Gene Date: 2011-07-19 Impact factor: 3.688

6. Inducible processing of interferon regulatory factor-2.

Authors: V J Palombella; T Maniatis
Journal: Mol Cell Biol Date: 1992-08 Impact factor: 4.272

7. Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7.

Authors: I Marié; J E Durbin; D E Levy
Journal: EMBO J Date: 1998-11-16 Impact factor: 11.598

8. The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds.

Authors: Y Kanno; C A Kozak; C Schindler; P H Driggers; D L Ennist; S L Gleason; J E Darnell; K Ozato
Journal: Mol Cell Biol Date: 1993-07 Impact factor: 4.272

9. Antiviral activity of limitin against encephalomyocarditis virus, herpes simplex virus, and mouse hepatitis virus: diverse requirements by limitin and alpha interferon for interferon regulatory factor 1.

Authors: Shin-Ichiro Kawamoto; Kenji Oritani; Hideo Asada; Isao Takahashi; Jun Ishikawa; Hitoshi Yoshida; Masahide Yamada; Naoko Ishida; Hidetoshi Ujiie; Hiroaki Masaie; Yoshiaki Tomiyama; Yuji Matsuzawa
Journal: J Virol Date: 2003-09 Impact factor: 5.103

10. Interferon regulatory factor-1 (IRF-1) activates the synthetic IRF-1-responsive sequence (GAAAGT)4 in Saccharomyces cerevisiae.

Authors: A Sailer; K Nagata; D Näf; M Aebi; C Weissmann
Journal: Gene Expr Date: 1992