Literature DB >> 2106503

Eponemycin, a new antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity.

K Sugawara1, M Hatori, Y Nishiyama, K Tomita, H Kamei, M Konishi, T Oki.   

Abstract

Streptomyces hygroscopicus No. P247-71(ATCC 53709)produced a novel antibiotic eponemycin which exhibited specific in vivo antitumor effect against B16 melanoma. Structural studies assigned (4S)-1,2-epoxy-2-hydroxymethyl-4-(N-isooctanoyl-L- serylamino)-6-methylhept-6-ene-3-one to eponemycin which is unrelated to the known antitumor antibiotics.

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Year:  1990        PMID： 2106503     DOI： 10.7164/antibiotics.43.8

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  18 in total

Review 1.  The ubiquitin-proteasome pathway and proteasome inhibitors.

Authors:  J Myung; K B Kim; C M Crews
Journal:  Med Res Rev       Date:  2001-07       Impact factor: 12.944

2.  Nocardia asteroides strain GUH-2 induces proteasome inhibition and apoptotic death of cultured cells.

Authors:  Daniel P Barry; Blaine L Beaman
Journal:  Res Microbiol       Date:  2006-12-15       Impact factor: 3.992

Review 3.  Chemical genetics: exploring the role of the proteasome in cell biology using natural products and other small molecule proteasome inhibitors.

Authors:  Kyung Bo Kim; Craig M Crews
Journal:  J Med Chem       Date:  2008-04-05       Impact factor: 7.446

4.  The carmaphycins: new proteasome inhibitors exhibiting an α,β-epoxyketone warhead from a marine cyanobacterium.

Authors:  Alban R Pereira; Andrew J Kale; Andrew T Fenley; Tara Byrum; Hosana M Debonsi; Michael K Gilson; Frederick A Valeriote; Bradley S Moore; William H Gerwick
Journal:  Chembiochem       Date:  2012-03-01       Impact factor: 3.164

5.  Identifying the Minimal Enzymes Required for Biosynthesis of Epoxyketone Proteasome Inhibitors.

Authors:  Joyce Liu; Xuejun Zhu; Wenjun Zhang
Journal:  Chembiochem       Date:  2015-11-02       Impact factor: 3.164

6.  Development and characterization of proteasome inhibitors.

Authors:  Kyung Bo Kim; Fabiana N Fonseca; Craig M Crews
Journal:  Methods Enzymol       Date:  2005       Impact factor: 1.600

7.  Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity.

Authors:  L Meng; R Mohan; B H Kwok; M Elofsson; N Sin; C M Crews
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-31       Impact factor: 11.205

8.  Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors.

Authors:  Michelle Schorn; Judith Zettler; Joseph P Noel; Pieter C Dorrestein; Bradley S Moore; Leonard Kaysser
Journal:  ACS Chem Biol       Date:  2013-11-08       Impact factor: 5.100

Review 9.  From bortezomib to other inhibitors of the proteasome and beyond.

Authors:  Daniela Buac; Min Shen; Sara Schmitt; Fathima Rani Kona; Rahul Deshmukh; Zhen Zhang; Christine Neslund-Dudas; Bharati Mitra; Q Ping Dou
Journal:  Curr Pharm Des       Date:  2013       Impact factor: 3.116

10.  Peptide and Peptide-Like Modulators of 20S Proteasome Enzymatic Activity in Cancer Cells.

Authors:  Carlos García-Echeverría
Journal:  Int J Pept Res Ther       Date:  2006-03-04       Impact factor: 1.931
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