OBJECTIVE: Research on the role of environmental lead exposure in the complex etiology of premature birth has yielded inconsistent results. We assessed the trimester-specific effect of prenatal lead exposure on gestational age and risk of premature delivery. METHODS: We used linear and logistic regression to identify critical windows of susceptibility to lead exposure on gestational length. RESULTS: In single-trimester models, decreases in gestational length were most strongly associated with first and second trimester blood lead. In adjusted logistic regression models, a one-standard deviation increase in second trimester blood lead was associated with an odds ratio of prematurity of 1.75 (95% CI: 1.02, 3.02). CONCLUSIONS: Maternal whole blood lead levels measured during first and second trimesters yielded the most prominent inverse association with length of gestation and increased the risk of prematurity.
OBJECTIVE: Research on the role of environmental lead exposure in the complex etiology of premature birth has yielded inconsistent results. We assessed the trimester-specific effect of prenatal lead exposure on gestational age and risk of premature delivery. METHODS: We used linear and logistic regression to identify critical windows of susceptibility to lead exposure on gestational length. RESULTS: In single-trimester models, decreases in gestational length were most strongly associated with first and second trimester blood lead. In adjusted logistic regression models, a one-standard deviation increase in second trimester blood lead was associated with an odds ratio of prematurity of 1.75 (95% CI: 1.02, 3.02). CONCLUSIONS: Maternal whole blood lead levels measured during first and second trimesters yielded the most prominent inverse association with length of gestation and increased the risk of prematurity.
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Authors: Esther García-Esquinas; Beatriz Pérez-Gómez; Pablo Fernández-Navarro; Mario Antonio Fernández; Concha de Paz; Ana María Pérez-Meixeira; Elisa Gil; Andrés Iriso; Juan Carlos Sanz; Jenaro Astray; Margot Cisneros; Amparo de Santos; Ángel Asensio; José Miguel García-Sagredo; José Frutos García; Jesús Vioque; Gonzalo López-Abente; Marina Pollán; María José González; Mercedes Martínez; Nuria Aragonés Journal: BMC Public Health Date: 2013-09-12 Impact factor: 3.295
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