STUDY OBJECTIVES: The aim of our study was to investigate cardiovascular autonomic activity during wakefulness, using cardiovascular tests, in a population of children with OSAS. DESIGN: Prospective study. SETTING: Sleep unit of an academic center. PARTICIPANTS: We included 25 children (mean age 10.2 +/- 2.3 years) undergoing a diagnostic assessment for OSAS, and 25 age-matched healthy control subjects. All subjects underwent an overnight polysomnography and autonomic cardiovascular tests using parts of the Ewing test battery, which is a physiological test used for the assessment of autonomic function (head-up tilt test, Valsalva maneuver, deep breathing test). MEASUREMENTS AND RESULTS: Eighteen of 25 children with OSAS (11 males, mean age 9.4 +/- 1.7 years) concluded the study. OSAS patients had higher systolic blood pressure, diastolic blood pressure, baseline heart rate, the 30:15 index (which represents the RR interval at the 15th and 30th beats during the head up tilt test), and delta diastolic and systolic blood pressure during the head-up tilt test, while the heart rate variability during the deep breathing test was lower, compared with controls. A positive correlation between systolic and diastolic blood pressure and the apnea-hypopnea index (AHI), and negative between AHI and both the 30:15 index and Valsalva ratio, were found. Stepwise linear regression analysis detected a negative correlation between AHI and the 30:15 index and Valsalva ratio, a positive correlation between overnight mean oxygen saturation and delta heart rate, and between AHI and delta systolic blood pressure. CONCLUSIONS: Our data point to an increase in basal sympathetic activity during wakefulness and to an impaired reaction to several physiological stimuli, which is dependent on the severity of OSAS.
STUDY OBJECTIVES: The aim of our study was to investigate cardiovascular autonomic activity during wakefulness, using cardiovascular tests, in a population of children with OSAS. DESIGN: Prospective study. SETTING: Sleep unit of an academic center. PARTICIPANTS: We included 25 children (mean age 10.2 +/- 2.3 years) undergoing a diagnostic assessment for OSAS, and 25 age-matched healthy control subjects. All subjects underwent an overnight polysomnography and autonomic cardiovascular tests using parts of the Ewing test battery, which is a physiological test used for the assessment of autonomic function (head-up tilt test, Valsalva maneuver, deep breathing test). MEASUREMENTS AND RESULTS: Eighteen of 25 children with OSAS (11 males, mean age 9.4 +/- 1.7 years) concluded the study. OSAS patients had higher systolic blood pressure, diastolic blood pressure, baseline heart rate, the 30:15 index (which represents the RR interval at the 15th and 30th beats during the head up tilt test), and delta diastolic and systolic blood pressure during the head-up tilt test, while the heart rate variability during the deep breathing test was lower, compared with controls. A positive correlation between systolic and diastolic blood pressure and the apnea-hypopnea index (AHI), and negative between AHI and both the 30:15 index and Valsalva ratio, were found. Stepwise linear regression analysis detected a negative correlation between AHI and the 30:15 index and Valsalva ratio, a positive correlation between overnight mean oxygen saturation and delta heart rate, and between AHI and delta systolic blood pressure. CONCLUSIONS: Our data point to an increase in basal sympathetic activity during wakefulness and to an impaired reaction to several physiological stimuli, which is dependent on the severity of OSAS.
Authors: Mirja Quante; Rui Wang; Jia Weng; Carol L Rosen; Raouf Amin; Susan L Garetz; Eliot Katz; Shalini Paruthi; Raanan Arens; Hiren Muzumdar; Carole L Marcus; Susan Ellenberg; Susan Redline Journal: Sleep Date: 2015-09-01 Impact factor: 5.849
Authors: Michael K Stickland; Craig D Steinback; Andrew R Steele; Lindsey F Berthelsen; Graham M Fraser; Devin B Phillips; Desi P Fuhr; Eric Y L Wong Journal: Clin Auton Res Date: 2021-02-09 Impact factor: 4.435
Authors: Lisa M Walter; Sarah N Biggs; Lauren C Nisbet; Aidan J Weichard; Samantha L Hollis; Margot J Davey; Vicki Anderson; Gillian M Nixon; Rosemary S C Horne Journal: Sleep Breath Date: 2015-10-02 Impact factor: 2.816
Authors: Mona F Philby; Secil Aydinoz; David Gozal; Selim Kilic; Rakesh Bhattacharjee; Hari P Bandla; Leila Kheirandish-Gozal Journal: Sleep Med Date: 2015-06-26 Impact factor: 3.492
Authors: Lisa M Walter; Gillian M Nixon; Margot J Davey; Vicki Anderson; Adrian M Walker; Rosemary S C Horne Journal: Sleep Breath Date: 2012-06-09 Impact factor: 2.816
Authors: David Gozal; Leila Kheirandish-Gozal; Rakesh Bhattacharjee; Helena Molero-Ramirez; Hui-Leng Tan; Hari P R Bandla Journal: J Pediatr Date: 2013-06-28 Impact factor: 4.406