Literature DB >> 21057966

Microglia activation is related to substantia nigra echogenicity.

D Berg1, J Godau, P Riederer, M Gerlach, T Arzberger.   

Abstract

Hyperechogenicity of the substantia nigra (SN) is a sensitive marker for Parkinson's disease (PD). Previously, a relation between SN echogenicity and iron as well as neuromelanin content could be described in 60 human brains. In the present study on a subset of 33 brains, SN echogenicity was found to be correlated with microglia activation (ρ = 0.46, p = 0.008) after correction for iron and neuromelanin content. These findings strengthen the hypothesis of a close pathophysiological connection between SN hyperechogenicity and PD pathology.

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Year:  2010        PMID： 21057966     DOI： 10.1007/s00702-010-0504-6

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  18 in total

Review 1.  Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention.

Authors:  Malú G Tansey; Melissa K McCoy; Tamy C Frank-Cannon
Journal:  Exp Neurol       Date:  2007-07-17       Impact factor: 5.330

2.  Identification of L-ferritin in neuromelanin granules of the human substantia nigra: a targeted proteomics approach.

Authors:  Florian Tribl; Esther Asan; Thomas Arzberger; Thomas Tatschner; Elmar Langenfeld; Helmut E Meyer; Gerhard Bringmann; Peter Riederer; Manfred Gerlach; Katrin Marcus
Journal:  Mol Cell Proteomics       Date:  2009-03-24       Impact factor: 5.911

3.  Detection of a monocyte/macrophage differentiation antigen in routinely processed paraffin-embedded tissues by monoclonal antibody Ki-M1P.

Authors:  H J Radzun; M L Hansmann; H J Heidebrecht; S Bödewadt-Radzun; H H Wacker; H Kreipe; H Lumbeck; C Hernandez; C Kuhn; M R Parwaresch
Journal:  Lab Invest       Date:  1991-09       Impact factor: 5.662

4.  In vivo detection of iron and neuromelanin by transcranial sonography: a new approach for early detection of substantia nigra damage.

Authors:  Luigi Zecca; Daniela Berg; Thomas Arzberger; Petra Ruprecht; Wolf D Rausch; Massimo Musicco; Davide Tampellini; Peter Riederer; Manfred Gerlach; Georg Becker
Journal:  Mov Disord       Date:  2005-10       Impact factor: 10.338

5.  Echogenicity of the substantia nigra: association with increased iron content and marker for susceptibility to nigrostriatal injury.

Authors:  Daniela Berg; Wolfgang Roggendorf; Ute Schröder; Rüdiger Klein; Thomas Tatschner; Peter Benz; Oliver Tucha; Michael Preier; Klaus W Lange; Karlheinz Reiners; Manfred Gerlach; Georg Becker
Journal:  Arch Neurol       Date:  2002-06

6.  Degeneration of nigrostriatal dopaminergic neurons increases iron within the substantia nigra: a histochemical and neurochemical study.

Authors:  E Oestreicher; G J Sengstock; P Riederer; C W Olanow; A J Dunn; G W Arendash
Journal:  Brain Res       Date:  1994-10-10       Impact factor: 3.252

Review 7.  Central role of alpha-synuclein oligomers in neurodegeneration in Parkinson disease.

Authors:  Aleksey G Kazantsev; Alexander M Kolchinsky
Journal:  Arch Neurol       Date:  2008-12

Review 8.  Glial reactions in Parkinson's disease.

Authors:  Patrick L McGeer; Edith G McGeer
Journal:  Mov Disord       Date:  2008-03-15       Impact factor: 10.338

9.  The specificity and sensitivity of transcranial ultrasound in the differential diagnosis of Parkinson's disease: a prospective blinded study.

Authors:  Alexandra Gaenslen; Barbara Unmuth; Jana Godau; Inga Liepelt; Adriana Di Santo; Katherine Johanna Schweitzer; Thomas Gasser; Hans-Jürgen Machulla; Matthias Reimold; Kenneth Marek; Daniela Berg
Journal:  Lancet Neurol       Date:  2008-04-03       Impact factor: 44.182

10.  Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes.

Authors:  L Zecca; M Gallorini; V Schünemann; A X Trautwein; M Gerlach; P Riederer; P Vezzoni; D Tampellini
Journal:  J Neurochem       Date:  2001-03       Impact factor: 5.372
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  24 in total

1.  Substantia nigra echogenicity in Parkinson's disease: relation to serum iron and C-reactive protein.

Authors:  Uwe Walter; Rike Witt; Alexander Wolters; Matthias Wittstock; Reiner Benecke
Journal:  J Neural Transm (Vienna)       Date:  2011-05-31       Impact factor: 3.575

Review 2.  Substantia nigra hyperechogenicity is a risk marker of Parkinson's disease: yes.

Authors:  Daniela Berg
Journal:  J Neural Transm (Vienna)       Date:  2011-01-05       Impact factor: 3.575

3.  Transcranial sonography in pantothenate kinase-associated neurodegeneration.

Authors:  Vladimir S Kostić; Marina Svetel; Milija Mijajlović; Aleksandra Pavlović; Milica Ječmenica-Lukić; Duško Kozić; Dušan Kozić
Journal:  J Neurol       Date:  2011-11-05       Impact factor: 4.849

4.  Upper limb function in children with attention-deficit/hyperactivity disorder (ADHD).

Authors:  Elizabeth Hotham; Miranda Haberfield; Susan Hillier; Jason M White; Gabrielle Todd
Journal:  J Neural Transm (Vienna)       Date:  2017-12-12       Impact factor: 3.575

5.  Hand function is impaired in healthy older adults at risk of Parkinson's disease.

Authors:  Gabrielle Todd; Miranda Haberfield; Patrick L Faulkner; Caroline Rae; Michael Hayes; Robert A Wilcox; Janet L Taylor; Simon C Gandevia; Jana Godau; Daniela Berg; Olivier Piguet; Kay L Double
Journal:  J Neural Transm (Vienna)       Date:  2014-05-03       Impact factor: 3.575

6.  Neonatal exposure to lipopolysaccharide enhances vulnerability of nigrostriatal dopaminergic neurons to rotenone neurotoxicity in later life.

Authors:  Lir-Wan Fan; Lu-Tai Tien; Rick C S Lin; Kimberly L Simpson; Philip G Rhodes; Zhengwei Cai
Journal:  Neurobiol Dis       Date:  2011-07-28       Impact factor: 5.996

7.  Transcranial sonography image characteristics in different Parkinson's disease subtypes.

Authors:  Ai Yan Sheng; Ying Chun Zhang; Yu Jing Sheng; Cai Shan Wang; Ying Zhang; Hua Hu; Wei Feng Luo; CHun-Feng LIu
Journal:  Neurol Sci       Date:  2017-07-19       Impact factor: 3.307

8.  Transcranial sonography and functional imaging in glucocerebrosidase mutation Parkinson disease.

Authors:  M J Barrett; J Hagenah; V Dhawan; S Peng; K Stanley; D Raymond; A Deik; S J Gross; N Schreiber-Agus; A Mirelman; K Marder; L J Ozelius; D Eidelberg; S B Bressman; R Saunders-Pullman
Journal:  Parkinsonism Relat Disord       Date:  2012-10-10       Impact factor: 4.891

9.  Neonatal systemic exposure to lipopolysaccharide enhances susceptibility of nigrostriatal dopaminergic neurons to rotenone neurotoxicity in later life.

Authors:  Zhengwei Cai; Lir-Wan Fan; Asuka Kaizaki; Lu-Tai Tien; Tangeng Ma; Yi Pang; Shuying Lin; Rick C S Lin; Kimberly L Simpson
Journal:  Dev Neurosci       Date:  2013-02-22       Impact factor: 2.984

10.  The predictive power of transcranial sonography in movement disorders: a longitudinal cohort study.

Authors:  Daniela Monaco; Daniela Berg; Astrid Thomas; Vincenzo Di Stefano; Filomena Barbone; Michela Vitale; Camilla Ferrante; Laura Bonanni; Marta Di Nicola; Tonia Garzarella; Luciano Paolo Marchionno; Giovanni Malferrari; Rocco Di Mascio; Marco Onofrj; Raffaella Franciotti
Journal:  Neurol Sci       Date:  2018-08-07       Impact factor: 3.307
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