Literature DB >> 19064744

Central role of alpha-synuclein oligomers in neurodegeneration in Parkinson disease.

Aleksey G Kazantsev1, Alexander M Kolchinsky.   

Abstract

Selective death of nigrostriatal neurons, which leads to Parkinson disease, is explained by misfolding of brain protein alpha-synuclein. Herein, we review the data supporting this concept, propose a scheme of events leading to synuclein-induced neuronal death, and discuss protein deacetylase sirtuins as new potential therapeutic targets involved in this process.

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Year:  2008        PMID： 19064744     DOI： 10.1001/archneur.65.12.1577

Source DB:  PubMed          Journal:  Arch Neurol        ISSN： 0003-9942


  30 in total

1.  Rotenone decreases intracellular aldehyde dehydrogenase activity: implications for the pathogenesis of Parkinson's disease.

Authors:  David S Goldstein; Patti Sullivan; Adele Cooney; Yunden Jinsmaa; Irwin J Kopin; Yehonatan Sharabi
Journal:  J Neurochem       Date:  2015-02-25       Impact factor: 5.372

2.  Divalent metal ions enhance DOPAL-induced oligomerization of alpha-synuclein.

Authors:  Yunden Jinsmaa; Patricia Sullivan; Daniel Gross; Adele Cooney; Yehonatan Sharabi; David S Goldstein
Journal:  Neurosci Lett       Date:  2014-03-23       Impact factor: 3.046

3.  Microglia activation is related to substantia nigra echogenicity.

Authors:  D Berg; J Godau; P Riederer; M Gerlach; T Arzberger
Journal:  J Neural Transm (Vienna)       Date:  2010-11-06       Impact factor: 3.575

4.  A novel strategy for the targeted analysis of protein and peptide metabolites.

Authors:  Nicholas A Williamson; Charles Reilly; Chor-Teck Tan; Sri-Harsha Ramarathinam; Alun Jones; Christie L Hunter; Francis R Rooney; Anthony W Purcell
Journal:  Proteomics       Date:  2010-12-15       Impact factor: 3.984

Review 5.  Synaptic protein alterations in Parkinson's disease.

Authors:  Ilse S Pienaar; David Burn; Christopher Morris; David Dexter
Journal:  Mol Neurobiol       Date:  2011-12-29       Impact factor: 5.590

6.  Increased expression of α-synuclein by SNCA duplication is associated with resistance to toxic stimuli.

Authors:  Han-Joon Kim; Beom S Jeon; Min-Yung Yoon; Sung-Sup Park; Kwang-Woo Lee
Journal:  J Mol Neurosci       Date:  2012-03-06       Impact factor: 3.444

7.  Prenatal LPS increases inflammation in the substantia nigra of Gdnf heterozygous mice.

Authors:  Ann-Charlotte Granholm; Vandana Zaman; Jennifer Godbee; Michael Smith; Riad Ramadan; Claudia Umphlet; Patrick Randall; Narayan R Bhat; Baerbel Rohrer; Lawrence D Middaugh; Heather A Boger
Journal:  Brain Pathol       Date:  2010-12-08       Impact factor: 6.508

8.  Vesicular uptake blockade generates the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde in PC12 cells: relevance to the pathogenesis of Parkinson's disease.

Authors:  David S Goldstein; Patti Sullivan; Adele Cooney; Yunden Jinsmaa; Rachel Sullivan; Daniel J Gross; Courtney Holmes; Irwin J Kopin; Yehonatan Sharabi
Journal:  J Neurochem       Date:  2012-10-25       Impact factor: 5.372

Review 9.  Recent advances in our understanding of neurodegeneration.

Authors:  Kurt A Jellinger
Journal:  J Neural Transm (Vienna)       Date:  2009-06-05       Impact factor: 3.575

Review 10.  Recent advances in α-synuclein functions, advanced glycation, and toxicity: implications for Parkinson's disease.

Authors:  Erika Guerrero; P Vasudevaraju; Muralidhar L Hegde; G B Britton; K S Rao
Journal:  Mol Neurobiol       Date:  2012-08-26       Impact factor: 5.590
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