| Literature DB >> 21055808 |
Alexandra S Weiner1, Olga V Beresina, Elena N Voronina, Elena N Voropaeva, Uljana A Boyarskih, Tatiana I Pospelova, Maxim L Filipenko.
Abstract
We investigated the role of single nucleotide polymorphisms (SNPs) in the folate-metabolizing genes MTHFR, MTR, MTRR, MTHFD, CBS and SHMT in regulating genetic susceptibility to Non-Hodgkin's lymphoma (NHL). We determined the allele and genotype frequencies in the case group (146 patients with NHL) and the control group (540 blood donors). A significant association with NHL was observed only for MTHFD1 G1958A (allele G OR=1.382, P=0.05; genotype GA OR=2.316, P=0.01; genotype GG OR=2.153, P=0.03). After additional stratification of case and control groups according to sex and tumor type association of MTHFD1 G1958A with NHL was observed only in high-grade NHL subgroup (allele G OR=1.664, P=0.01) and in women subgroup (allele G OR=2.043, P=0.009). Meta-analysis for SNPs in the MTHFR, MTR, MTRR and SHMT revealed a reducing effect of the MTR 2756G allele on the risk of NHL (OR=0.902; 95% CI 0.821-0.991, P=0.03).Entities:
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Year: 2010 PMID： 21055808 DOI： 10.1016/j.leukres.2010.10.004
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156