Literature DB >> 22353665

Polymorphisms in 1-carbon metabolism, epigenetics and folate-related pathologies.

Patrick J Stover1.   

Abstract

Folate-mediated 1-carbon metabolism is a network of interconnected metabolic pathways necessary for the synthesis of purine nucleotides, thymidylate and the remethylation of homocysteine to methionine. Disruptions in this pathway influence both DNA synthesis and stability and chromatin methylation, and result from nutritional deficiencies and common gene variants. The mechanisms underlying folate-associated pathologies and developmental anomalies have yet to be established. This review focuses on the relationships among folate-mediated 1-carbon metabolism, chromatin methylation and human disease, and the role of gene-nutrient interactions in modifying epigenetic processes.
Copyright © 2012 S. Karger AG, Basel.

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Year:  2012        PMID： 22353665      PMCID： PMC3696357          DOI： 10.1159/000334586

Source DB:  PubMed          Journal:  J Nutrigenet Nutrigenomics        ISSN： 1661-6499


  128 in total

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Journal:  Am J Med Genet       Date:  1999-05-21

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Journal:  J Biol Chem       Date:  2009-05-29       Impact factor: 5.157

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Journal:  Biochemistry       Date:  1981-03-03       Impact factor: 3.162

10.  Vitamin B12 is a strong determinant of low methionine synthase activity and DNA hypomethylation in gastrectomized rats.

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Journal:  Digestion       Date:  2003-11-28       Impact factor: 3.216
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  35 in total

Review 1.  Nutritional models of foetal programming and nutrigenomic and epigenomic dysregulations of fatty acid metabolism in the liver and heart.

Authors:  Jean-Louis Guéant; Rania Elakoum; Olivier Ziegler; David Coelho; Eva Feigerlova; Jean-Luc Daval; Rosa-Maria Guéant-Rodriguez
Journal:  Pflugers Arch       Date:  2013-09-03       Impact factor: 3.657

2.  Arsenic trioxide targets MTHFD1 and SUMO-dependent nuclear de novo thymidylate biosynthesis.

Authors:  Elena Kamynina; Erica R Lachenauer; Aislyn C DiRisio; Rebecca P Liebenthal; Martha S Field; Patrick J Stover
Journal:  Proc Natl Acad Sci U S A       Date:  2017-03-06       Impact factor: 11.205

Review 3.  Epigenetics and nutritional environmental signals.

Authors:  Elizabeth A Mazzio; Karam F A Soliman
Journal:  Integr Comp Biol       Date:  2014-05-26       Impact factor: 3.326

Review 4.  Do Gametes Woo? Evidence for Their Nonrandom Union at Fertilization.

Authors:  Joseph H Nadeau
Journal:  Genetics       Date:  2017-10       Impact factor: 4.562

5.  Plasma 1-carbon metabolites and academic achievement in 15-yr-old adolescents.

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Journal:  FASEB J       Date:  2016-01-04       Impact factor: 5.191

Review 6.  Vitamin B-12 and Perinatal Health.

Authors:  Julia L Finkelstein; Alexander J Layden; Patrick J Stover
Journal:  Adv Nutr       Date:  2015-09-15       Impact factor: 8.701

7.  Adherence to Mediterranean diet during pregnancy and serum lipid, lipoprotein and homocysteine concentrations at birth.

Authors:  Eva Gesteiro; Sara Bastida; Beatriz Rodríguez Bernal; Francisco J Sánchez-Muniz
Journal:  Eur J Nutr       Date:  2014-11-20       Impact factor: 5.614

8.  Vitamin B-12 and the Gastrointestinal Microbiome: A Systematic Review.

Authors:  Heather M Guetterman; Samantha L Huey; Rob Knight; Allison M Fox; Saurabh Mehta; Julia L Finkelstein
Journal:  Adv Nutr       Date:  2021-10-06       Impact factor: 8.701

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Authors:  Lynn B Bailey; Patrick J Stover; Helene McNulty; Michael F Fenech; Jesse F Gregory; James L Mills; Christine M Pfeiffer; Zia Fazili; Mindy Zhang; Per M Ueland; Anne M Molloy; Marie A Caudill; Barry Shane; Robert J Berry; Regan L Bailey; Dorothy B Hausman; Ramkripa Raghavan; Daniel J Raiten
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Authors:  William G Kaelin; Steven L McKnight
Journal:  Cell       Date:  2013-03-28       Impact factor: 41.582
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