BACKGROUND: This report is a further analysis of a study designed to determine clinical and microbial risk indicators for progressing periodontitis. METHODS: One hundred ninety subjects who were periodontally healthy or had early signs of periodontitis (age range: 20 to 40 years) were monitored clinically at 6-month intervals followed by supragingival cleaning. At each visit, gingival crevicular fluid (GCF) and blood were collected for determination of interleukin (IL)-1β content (in GCF) and IL-1 genotype (in blood). Interproximal sites with a >1.5-mm increase in clinical attachment over 18 months were considered disease active. Characteristics were compared between active and inactive subjects. RESULTS: IL-1β levels in GCF increased with the severity of disease and correlated well with clinical signs of incipient disease. However, the IL-1 genotype did not show any significant associations with disease or the extent of disease. CONCLUSION: Indicators of inflammation may be important clinical determinants of future periodontal disease progression, but the IL-1 genotype was not a risk indictor for early (slight) periodontitis as defined in this subject population.
BACKGROUND: This report is a further analysis of a study designed to determine clinical and microbial risk indicators for progressing periodontitis. METHODS: One hundred ninety subjects who were periodontally healthy or had early signs of periodontitis (age range: 20 to 40 years) were monitored clinically at 6-month intervals followed by supragingival cleaning. At each visit, gingival crevicular fluid (GCF) and blood were collected for determination of interleukin (IL)-1β content (in GCF) and IL-1 genotype (in blood). Interproximal sites with a >1.5-mm increase in clinical attachment over 18 months were considered disease active. Characteristics were compared between active and inactive subjects. RESULTS:IL-1β levels in GCF increased with the severity of disease and correlated well with clinical signs of incipient disease. However, the IL-1 genotype did not show any significant associations with disease or the extent of disease. CONCLUSION: Indicators of inflammation may be important clinical determinants of future periodontal disease progression, but the IL-1 genotype was not a risk indictor for early (slight) periodontitis as defined in this subject population.
Authors: H Hasturk; A Kantarci; T Ohira; M Arita; N Ebrahimi; N Chiang; N A Petasis; B D Levy; C N Serhan; T E Van Dyke Journal: FASEB J Date: 2005-12-22 Impact factor: 5.191
Authors: Bryan S Michalowicz; James S Hodges; Anthony J DiAngelis; Virginia R Lupo; M John Novak; James E Ferguson; William Buchanan; James Bofill; Panos N Papapanou; Dennis A Mitchell; Stephen Matseoane; Pat A Tschida Journal: N Engl J Med Date: 2006-11-02 Impact factor: 91.245
Authors: Raed AlRowis; Hani S AlMoharib; Abdulrahman AlMubarak; Jagankumar Bhaskardoss; R S Preethanath; Sukumaran Anil Journal: J Int Oral Health Date: 2014-09