PURPOSE: We aimed to compare the diagnostic value of fine-needle aspiration cytology (FNAC) and fine-needle aspiration thyroglobulin measurements (FNA-Tg) for detecting cervical lymph node metastases from differentiated thyroid carcinomas. METHODS: This prospective study included 225 patients with neck node metastases or recurrences of papillary thyroid carcinoma. From the 225 patients, 255 lymph nodes were evaluated by FNAC and FNA-Tg. Final diagnoses confirmed by histological examination were compared to preoperative FNAC and FNA-Tg results. RESULTS: FNAC correctly diagnosed 212 metastatic lymph nodes but failed to diagnose 43 of them. FNA-Tg correctly diagnosed 253 metastatic lymph nodes but failed to diagnose two of them. FNA-Tg levels showed 100% sensitivity, 96% specificity, 99% diagnostic accuracy, a 99% positive predictive value (PPV) and a 100% negative predictive value (NPV) with a threshold level of FNA-Tg with a diagnostic accuracy 28.5 ng/ml. The specificity, diagnostic accuracy, PPV and NPV of FNA-Tg were significantly higher than those of FNAC. CONCLUSION: FNA-Tg measurement can be performed safely for the detection of lymph node metastasis in patients with differentiated thyroid carcinomas.
PURPOSE: We aimed to compare the diagnostic value of fine-needle aspiration cytology (FNAC) and fine-needle aspiration thyroglobulin measurements (FNA-Tg) for detecting cervical lymph node metastases from differentiated thyroid carcinomas. METHODS: This prospective study included 225 patients with neck node metastases or recurrences of papillary thyroid carcinoma. From the 225 patients, 255 lymph nodes were evaluated by FNAC and FNA-Tg. Final diagnoses confirmed by histological examination were compared to preoperative FNAC and FNA-Tg results. RESULTS: FNAC correctly diagnosed 212 metastatic lymph nodes but failed to diagnose 43 of them. FNA-Tg correctly diagnosed 253 metastatic lymph nodes but failed to diagnose two of them. FNA-Tg levels showed 100% sensitivity, 96% specificity, 99% diagnostic accuracy, a 99% positive predictive value (PPV) and a 100% negative predictive value (NPV) with a threshold level of FNA-Tg with a diagnostic accuracy 28.5 ng/ml. The specificity, diagnostic accuracy, PPV and NPV of FNA-Tg were significantly higher than those of FNAC. CONCLUSION: FNA-Tg measurement can be performed safely for the detection of lymph node metastasis in patients with differentiated thyroid carcinomas.
Authors: Sophie Leboulleux; Elizabeth Girard; Mathieu Rose; Jean Paul Travagli; Nadia Sabbah; Bernard Caillou; Dana M Hartl; Nathalie Lassau; Eric Baudin; Martin Schlumberger Journal: J Clin Endocrinol Metab Date: 2007-07-03 Impact factor: 5.958
Authors: David S Cooper; Gerard M Doherty; Bryan R Haugen; Bryan R Hauger; Richard T Kloos; Stephanie L Lee; Susan J Mandel; Ernest L Mazzaferri; Bryan McIver; Furio Pacini; Martin Schlumberger; Steven I Sherman; David L Steward; R Michael Tuttle Journal: Thyroid Date: 2009-11 Impact factor: 6.568
Authors: F Pacini; L Fugazzola; F Lippi; C Ceccarelli; R Centoni; P Miccoli; R Elisei; A Pinchera Journal: J Clin Endocrinol Metab Date: 1992-06 Impact factor: 5.958
Authors: R Elisei; M Schlumberger; A Driedger; C Reiners; R T Kloos; S I Sherman; B Haugen; C Corone; E Molinaro; L Grasso; S Leboulleux; I Rachinsky; M Luster; M Lassmann; N L Busaidy; R L Wahl; F Pacini; S Y Cho; J Magner; A Pinchera; P W Ladenson Journal: J Clin Endocrinol Metab Date: 2009-10-22 Impact factor: 5.958
Authors: Christine L H Snozek; Eugene P Chambers; Carl C Reading; Thomas J Sebo; J Woody Sistrunk; Ravinder J Singh; Stefan K G Grebe Journal: J Clin Endocrinol Metab Date: 2007-08-07 Impact factor: 5.958