PURPOSE: To investigate blood flow changes in retinal and optic nerve diseases with Doppler Fourier domain optical coherence tomography (OCT). METHODS: Sixty-two participants were divided into five groups: normal, glaucoma, nonarteritic ischemic optic neuropathy (NAION), treated proliferative diabetic retinopathy (PDR), and branch retinal vein occlusion (BRVO). Doppler OCT was used to scan concentric circles of 3.4- and 3.75-mm diameters around the optic nerve head. Flow in retinal veins was calculated from the OCT velocity profiles. Arterial and venous diameters were measured from OCT Doppler and reflectance images. RESULTS: Total retinal blood flow in normal subjects averaged 47.6 μL/min. The coefficient of variation of repeated measurements was 11% in normal eyes and 14% in diseased eyes. Eyes with glaucoma, NAION, treated PDR, and BRVO had significantly decreased retinal blood flow compared with normal eyes (P < 0.001). In glaucoma patients, the decrease in blood flow was highly correlated with the severity of visual field loss (P = 0.003). In NAION and BRVO patients, the hemisphere with more severe disease also had lower blood flow. CONCLUSIONS: Doppler OCT retinal blood flow measurements showed good repeatability and excellent correlation with visual field and clinical presentations. This approach could enhance our understanding of retinal and optic nerve diseases and facilitate the development of new therapies.
PURPOSE: To investigate blood flow changes in retinal and optic nerve diseases with Doppler Fourier domain optical coherence tomography (OCT). METHODS: Sixty-two participants were divided into five groups: normal, glaucoma, nonarteritic ischemic optic neuropathy (NAION), treated proliferative diabetic retinopathy (PDR), and branch retinal vein occlusion (BRVO). Doppler OCT was used to scan concentric circles of 3.4- and 3.75-mm diameters around the optic nerve head. Flow in retinal veins was calculated from the OCT velocity profiles. Arterial and venous diameters were measured from OCT Doppler and reflectance images. RESULTS: Total retinal blood flow in normal subjects averaged 47.6 μL/min. The coefficient of variation of repeated measurements was 11% in normal eyes and 14% in diseased eyes. Eyes with glaucoma, NAION, treated PDR, and BRVO had significantly decreased retinal blood flow compared with normal eyes (P < 0.001). In glaucomapatients, the decrease in blood flow was highly correlated with the severity of visual field loss (P = 0.003). In NAION and BRVO patients, the hemisphere with more severe disease also had lower blood flow. CONCLUSIONS: Doppler OCT retinal blood flow measurements showed good repeatability and excellent correlation with visual field and clinical presentations. This approach could enhance our understanding of retinal and optic nerve diseases and facilitate the development of new therapies.
Authors: Maciej Wojtkowski; Rainer Leitgeb; Andrzej Kowalczyk; Tomasz Bajraszewski; Adolf F Fercher Journal: J Biomed Opt Date: 2002-07 Impact factor: 3.170
Authors: Brian White; Mark Pierce; Nader Nassif; Barry Cense; B Park; Guillermo Tearney; Brett Bouma; Teresa Chen; Johannes de Boer Journal: Opt Express Date: 2003-12-15 Impact factor: 3.894
Authors: Zhongwei Zhi; Jennifer R Chao; Tomasz Wietecha; Kelly L Hudkins; Charles E Alpers; Ruikang K Wang Journal: Invest Ophthalmol Vis Sci Date: 2014-02-20 Impact factor: 4.799
Authors: ByungKun Lee; WooJhon Choi; Jonathan J Liu; Chen D Lu; Joel S Schuman; Gadi Wollstein; Jay S Duker; Nadia K Waheed; James G Fujimoto Journal: Invest Ophthalmol Vis Sci Date: 2015-04 Impact factor: 4.799
Authors: John C Hwang; Ranjith Konduru; Xinbo Zhang; Ou Tan; Brian A Francis; Rohit Varma; Mitra Sehi; David S Greenfield; Srinivas R Sadda; David Huang Journal: Invest Ophthalmol Vis Sci Date: 2012-05-17 Impact factor: 4.799
Authors: Shawn Philip; Ahmad Najafi; Apichat Tantraworasin; Toco Y P Chui; Richard B Rosen; Robert Ritch Journal: Invest Ophthalmol Vis Sci Date: 2019-03-01 Impact factor: 4.799
Authors: Mitra Sehi; Iman Goharian; Ranjith Konduru; Ou Tan; Sowmya Srinivas; Srinivas R Sadda; Brian A Francis; David Huang; David S Greenfield Journal: Ophthalmology Date: 2013-11-28 Impact factor: 12.079