OBJECTIVE: To examine whether parental, foetal and postnatal characteristics and growth patterns in foetal life and infancy are associated with bone mass at 6 months, as bone acquisition seems to be associated with genetic and environmental factors. DESIGN: This study was embedded in the Generation R Study, a prospective cohort from early foetal life onwards. PATIENTS AND MEASUREMENTS: Bone mineral density (BMD) and bone mineral content (BMC) total body (TB) and BMD lumbar spine (LS) were measured by dual-energy X-ray absorptiometry in 252 infants at 6 months. Parental, foetal and postnatal data were collected by physical and foetal ultrasound examinations and questionnaires. RESULTS: Maternal, foetal and postnatal anthropometrics were positively associated with BMD(TB) and BMC(TB) at 6 months, but only postnatal anthropometrics were associated with BMD(LS) . A gain in weight-SD-score during foetal life and prenatal catch-up in weight were positively associated with BMD(TB) . After birth, a gain in weight-SD-score was positively associated with BMD(LS) and bone mineral apparent density (BMAD(LS) ). The effect was strongest between 6 weeks and 6 months. Catch-up in weight was associated with a lower probability of low (lowest quartile of) BMD(TB) and BMD(LS) . Children remaining in the first tertile of weight from birth to 6 months had a much higher risk of low BMD(TB) at 6 months [OR (95% CI): 15 (2, 88)]. CONCLUSIONS: Our findings suggest that growth patterns in foetal and postnatal life are associated with bone mass in infancy and may have consequences for bone mass in later life. Follow-up studies are needed to assess whether and to what extent maternal anthropometrics, foetal and postnatal growth patterns have an effect on bone status in adulthood.
OBJECTIVE: To examine whether parental, foetal and postnatal characteristics and growth patterns in foetal life and infancy are associated with bone mass at 6 months, as bone acquisition seems to be associated with genetic and environmental factors. DESIGN: This study was embedded in the Generation R Study, a prospective cohort from early foetal life onwards. PATIENTS AND MEASUREMENTS: Bone mineral density (BMD) and bone mineral content (BMC) total body (TB) and BMD lumbar spine (LS) were measured by dual-energy X-ray absorptiometry in 252 infants at 6 months. Parental, foetal and postnatal data were collected by physical and foetal ultrasound examinations and questionnaires. RESULTS: Maternal, foetal and postnatal anthropometrics were positively associated with BMD(TB) and BMC(TB) at 6 months, but only postnatal anthropometrics were associated with BMD(LS) . A gain in weight-SD-score during foetal life and prenatal catch-up in weight were positively associated with BMD(TB) . After birth, a gain in weight-SD-score was positively associated with BMD(LS) and bone mineral apparent density (BMAD(LS) ). The effect was strongest between 6 weeks and 6 months. Catch-up in weight was associated with a lower probability of low (lowest quartile of) BMD(TB) and BMD(LS) . Children remaining in the first tertile of weight from birth to 6 months had a much higher risk of low BMD(TB) at 6 months [OR (95% CI): 15 (2, 88)]. CONCLUSIONS: Our findings suggest that growth patterns in foetal and postnatal life are associated with bone mass in infancy and may have consequences for bone mass in later life. Follow-up studies are needed to assess whether and to what extent maternal anthropometrics, foetal and postnatal growth patterns have an effect on bone status in adulthood.
Authors: Teresa Monjardino; Ana Henriques; Carla Moreira; Teresa Rodrigues; Nuno Adubeiro; Luísa Nogueira; Cyrus Cooper; Ana Cristina Santos; Raquel Lucas Journal: J Bone Miner Res Date: 2018-11-06 Impact factor: 6.741
Authors: J Martínez-Mesa; M C Restrepo-Méndez; D A González; F C Wehrmeister; B L Horta; M R Domingues; A M B Menezes Journal: Osteoporos Int Date: 2012-08-29 Impact factor: 4.507
Authors: Cyrus Cooper; Nicholas C Harvey; Nicholas J Bishop; Stephen Kennedy; Aris T Papageorghiou; Inez Schoenmakers; Robert Fraser; Saurabh V Gandhi; Andrew Carr; Stefania D'Angelo; Sarah R Crozier; Rebecca J Moon; Nigel K Arden; Elaine M Dennison; Keith M Godfrey; Hazel M Inskip; Ann Prentice; M Zulf Mughal; Richard Eastell; David M Reid; M Kassim Javaid Journal: Lancet Diabetes Endocrinol Date: 2016-03-02 Impact factor: 32.069
Authors: D Manousaki; F Rauch; G Chabot; J Dubois; M Fiscaletti; N Alos Journal: J Musculoskelet Neuronal Interact Date: 2016-09-07 Impact factor: 2.041