Literature DB >> 21047965

The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor contains an immunoreceptor tyrosine-based inhibitory motif that activates Shp2.

Nicola Philpott1, Thomas Bakken, Christopher Pennell, Liwei Chen, Jie Wu, Mark Cannon.   

Abstract

The Kaposi's sarcoma-associated herpesvirus (KSHV) G protein-coupled receptor (vGPCR) is a constitutively active, highly angiogenic homologue of the interleukin-8 (IL-8) receptors that signals in part via the cytoplasmic protein tyrosine phosphatase Shp2. We show that vGPCR contains a bona fide immunoreceptor tyrosine-based inhibitory motif (ITIM) that binds and constitutively activates Shp2.

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Year:  2010        PMID： 21047965      PMCID： PMC3020031          DOI： 10.1128/JVI.01362-10

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  26 in total

Review 1.  ITAMs versus ITIMs: striking a balance during cell regulation.

Authors:  Daniel D Billadeau; Paul J Leibson
Journal:  J Clin Invest       Date:  2002-01       Impact factor: 14.808

2.  Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes.

Authors:  Silvia Montaner; Akrit Sodhi; Alfredo Molinolo; Thomas H Bugge; Earl T Sawai; Yunsheng He; Yi Li; Patricio E Ray; J Silvio Gutkind
Journal:  Cancer Cell       Date:  2003-01       Impact factor: 31.743

Review 3.  The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling.

Authors:  Benjamin G Neel; Haihua Gu; Lily Pao
Journal:  Trends Biochem Sci       Date:  2003-06       Impact factor: 13.807

Review 4.  The druggable genome.

Authors:  Andrew L Hopkins; Colin R Groom
Journal:  Nat Rev Drug Discov       Date:  2002-09       Impact factor: 84.694

5.  Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma.

Authors:  E Cesarman; R G Nador; F Bai; R A Bohenzky; J J Russo; P S Moore; Y Chang; D M Knowles
Journal:  J Virol       Date:  1996-11       Impact factor: 5.103

6.  Recruitment of tyrosine phosphatase HCP by the killer cell inhibitor receptor.

Authors:  D N Burshtyn; A M Scharenberg; N Wagtmann; S Rajagopalan; K Berrada; T Yi; J P Kinet; E O Long
Journal:  Immunity       Date:  1996-01       Impact factor: 31.745

7.  Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation.

Authors:  L Arvanitakis; E Geras-Raaka; A Varma; M C Gershengorn; E Cesarman
Journal:  Nature       Date:  1997-01-23       Impact factor: 49.962

8.  Increasing Kaposi's sarcoma-associated herpesvirus seroprevalence with age in a highly Kaposi's sarcoma endemic region, Zambia in 1985.

Authors:  S J Olsen; Y Chang; P S Moore; R J Biggar; M Melbye
Journal:  AIDS       Date:  1998-10-01       Impact factor: 4.177

9.  Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma.

Authors:  Y Chang; E Cesarman; M S Pessin; F Lee; J Culpepper; D M Knowles; P S Moore
Journal:  Science       Date:  1994-12-16       Impact factor: 47.728

10.  Detection of Kaposi sarcoma associated herpesvirus in peripheral blood of HIV-infected individuals and progression to Kaposi's sarcoma.

Authors:  D Whitby; M R Howard; M Tenant-Flowers; N S Brink; A Copas; C Boshoff; T Hatzioannou; F E Suggett; D M Aldam; A S Denton
Journal:  Lancet       Date:  1995-09-23       Impact factor: 79.321
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  5 in total

Review 1.  Molecular biology of human herpesvirus 8: novel functions and virus-host interactions implicated in viral pathogenesis and replication.

Authors:  Emily Cousins; John Nicholas
Journal:  Recent Results Cancer Res       Date:  2014

2.  Characterization of G protein coupling mediated by the conserved D134(3.49) of DRY motif, M241(6.34), and F251(6.44) residues on human CXCR1.

Authors:  Xinbing Han; Yan Feng; Xinhua Chen; Craig Gerard; William A Boisvert
Journal:  FEBS Open Bio       Date:  2015-03-07       Impact factor: 2.693

Review 3.  Modulation of Innate Immune Signaling Pathways by Herpesviruses.

Authors:  Qizhi Liu; Youliang Rao; Mao Tian; Shu Zhang; Pinghui Feng
Journal:  Viruses       Date:  2019-06-21       Impact factor: 5.048

4.  SHP-2 Mediates Cryptosporidium parvum Infectivity in Human Intestinal Epithelial Cells.

Authors:  Eunice A Varughese; Susan Kasper; Emily M Anneken; Jagjit S Yadav
Journal:  PLoS One       Date:  2015-11-10       Impact factor: 3.240

5.  CADM1 is essential for KSHV-encoded vGPCR-and vFLIP-mediated chronic NF-κB activation.

Authors:  Richard Hunte; Patricia Alonso; Remy Thomas; Cassandra Alexandria Bazile; Juan Carlos Ramos; Louise van der Weyden; Juan Dominguez-Bendala; Wasif Noor Khan; Noula Shembade
Journal:  PLoS Pathog       Date:  2018-04-26       Impact factor: 6.823
  5 in total

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