Literature DB >> 21047088

A mild Negishi cross-coupling of 2-heterocyclic organozinc reagents and aryl chlorides.

Michael R Luzung1, Jigar S Patel, Jingjun Yin.   

Abstract

A mild Negishi cross-coupling of 2-heterocyclic organozinc reagents and aryl chlorides is described. The use of Pd(2)(dba)(3) and X-Phos as a ligand provides high yields for many examples. An efficient method to generate the organozinc reagents at room temperature is also demonstrated.

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Year:  2010        PMID： 21047088     DOI： 10.1021/jo1018798

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  12 in total

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