OBJECTIVE: To evaluate the effect of embryo transfer number on singleton and twin pregnancy outcomes with one and two fetal heartbeats on early ultrasound, respectively. STUDY DESIGN: The study included 23,645 singleton and 14,083 twin live births from the SART-CORS Online database of assisted reproductive technology cycles for 2004-2006. The data were limited to fresh embryo transfers among women who had additional embryos cryopreserved during the same cycle, resulting either in one fetal heartbeat on early ultrasound and a singleton live birth, or two fetal heartbeats and a twin live birth. Data were categorized by number of embryos transferred; the reference group was one for singletons and two for twins. The primary outcome measure was moderate growth restriction (birthweight for gestation z-score < -1), adjusted for potential confounders. RESULTS: Risk for moderate growth restriction among singletons was increased by 15%, 23%, and 37%, respectively, with 2, 3, and > or = 4 embryos transferred, and among twins, by 50% and 105%, respectively, with 3 and > or = 4 embryos transferred. CONCLUSION: The data demonstrate a significant residual adverse effect on intrauterine growth from transfer of multiple embryos. Whether this effect is due to compromised embryo quality, degenerating implantation sites, or other etiology is unclear.
OBJECTIVE: To evaluate the effect of embryo transfer number on singleton and twin pregnancy outcomes with one and two fetal heartbeats on early ultrasound, respectively. STUDY DESIGN: The study included 23,645 singleton and 14,083 twin live births from the SART-CORS Online database of assisted reproductive technology cycles for 2004-2006. The data were limited to fresh embryo transfers among women who had additional embryos cryopreserved during the same cycle, resulting either in one fetal heartbeat on early ultrasound and a singleton live birth, or two fetal heartbeats and a twin live birth. Data were categorized by number of embryos transferred; the reference group was one for singletons and two for twins. The primary outcome measure was moderate growth restriction (birthweight for gestation z-score < -1), adjusted for potential confounders. RESULTS: Risk for moderate growth restriction among singletons was increased by 15%, 23%, and 37%, respectively, with 2, 3, and > or = 4 embryos transferred, and among twins, by 50% and 105%, respectively, with 3 and > or = 4 embryos transferred. CONCLUSION: The data demonstrate a significant residual adverse effect on intrauterine growth from transfer of multiple embryos. Whether this effect is due to compromised embryo quality, degenerating implantation sites, or other etiology is unclear.
Authors: Barbara Luke; Morton B Brown; Ethan Wantman; Judy E Stern; Valerie L Baker; Eric Widra; Charles C Coddington; William E Gibbons; Bradley J Van Voorhis; G David Ball Journal: Am J Obstet Gynecol Date: 2015-02-13 Impact factor: 8.661
Authors: Barbara Luke; Judy E Stern; Milton Kotelchuck; Eugene R Declercq; Mark D Hornstein; Daksha Gopal; Lan Hoang; Hafsatou Diop Journal: Fertil Steril Date: 2015-05-05 Impact factor: 7.329
Authors: Aaron K Styer; Barbara Luke; Wendy Vitek; Mindy S Christianson; Valerie L Baker; Alicia Y Christy; Alex J Polotsky Journal: Fertil Steril Date: 2016-03-18 Impact factor: 7.329
Authors: Barbara Luke; Judy E Stern; Mark D Hornstein; Milton Kotelchuck; Hafsatou Diop; Howard Cabral; Eugene R Declercq Journal: J Assist Reprod Genet Date: 2015-12-03 Impact factor: 3.412
Authors: Barbara Luke; Morton B Brown; Ethan Wantman; Nina E Forestieri; Marilyn L Browne; Sarah C Fisher; Mahsa M Yazdy; Mary K Ethen; Mark A Canfield; Hazel B Nichols; Sergio Oehninger; Kevin J Doody; Alastair G Sutcliffe; Carrie Williams; Michael L Eisenberg; Valerie L Baker; Caitlin R Sacha; Philip J Lupo Journal: J Assist Reprod Genet Date: 2021-02-05 Impact factor: 3.412