BACKGROUND: Venous thromboembolism has genetic determinants, but population-based data on familial risks are limited. OBJECTIVES: To examine the familial risk of venous thromboembolism. METHODS: We undertook a nationwide study of a cohort of patients with deep venous thrombosis or pulmonary embolism born after 1952. We used the Danish National Registry of Patients covering all Danish hospitals, for the years 1977 through 2009, to identify index cases of venous thromboembolism, and assessed the incidence among their siblings. We compared standardized incidence ratios (SIRs) of the observed and expected number of venous thromboembolism cases among siblings, using population-specific, gender-specific and age-specific incidence rates. RESULTS: We identified 30,179 siblings of 19,599 cases of venous thromboembolism. The incidence among siblings was 2.2 cases per 1000 person-years, representing a relative risk of 3.08 (95% confidence interval [CI] 2.80-3.39) as compared with the general population. The risk was higher for both men (SIR 3.36, 95% CI 2.96-3.82) and women (SIR 2.81, 95% CI 2.45-3.23). The risk was similar among siblings of index cases with venous thrombosis and those of index cases with pulmonary embolism. CONCLUSION: Venous thromboembolism has a strong familial component.
BACKGROUND:Venous thromboembolism has genetic determinants, but population-based data on familial risks are limited. OBJECTIVES: To examine the familial risk of venous thromboembolism. METHODS: We undertook a nationwide study of a cohort of patients with deep venous thrombosis or pulmonary embolism born after 1952. We used the Danish National Registry of Patients covering all Danish hospitals, for the years 1977 through 2009, to identify index cases of venous thromboembolism, and assessed the incidence among their siblings. We compared standardized incidence ratios (SIRs) of the observed and expected number of venous thromboembolism cases among siblings, using population-specific, gender-specific and age-specific incidence rates. RESULTS: We identified 30,179 siblings of 19,599 cases of venous thromboembolism. The incidence among siblings was 2.2 cases per 1000 person-years, representing a relative risk of 3.08 (95% confidence interval [CI] 2.80-3.39) as compared with the general population. The risk was higher for both men (SIR 3.36, 95% CI 2.96-3.82) and women (SIR 2.81, 95% CI 2.45-3.23). The risk was similar among siblings of index cases with venous thrombosis and those of index cases with pulmonary embolism. CONCLUSION:Venous thromboembolism has a strong familial component.
Authors: Francis Couturaud; Christophe Leroyer; Cecile Tromeur; Jim A Julian; Susan R Kahn; Jeffrey S Ginsberg; Philip S Wells; James D Douketis; Dominique Mottier; Clive Kearon Journal: Blood Date: 2014-07-21 Impact factor: 22.113
Authors: Benedetto Simone; Valerio De Stefano; Emanuele Leoncini; Jeppe Zacho; Ida Martinelli; Joseph Emmerich; Elena Rossi; Aaron R Folsom; Wassim Y Almawi; Pierre Y Scarabin; Martin den Heijer; Mary Cushman; Silvana Penco; Amparo Vaya; Pantep Angchaisuksiri; Gulfer Okumus; Donato Gemmati; Simona Cima; Nejat Akar; Kivilcim I Oguzulgen; Véronique Ducros; Christoph Lichy; Consuelo Fernandez-Miranda; Andrzej Szczeklik; José A Nieto; Jose Domingo Torres; Véronique Le Cam-Duchez; Petar Ivanov; Carlos Cantu-Brito; Veronika M Shmeleva; Mojka Stegnar; Dotun Ogunyemi; Suhair S Eid; Nicola Nicolotti; Emma De Feo; Walter Ricciardi; Stefania Boccia Journal: Eur J Epidemiol Date: 2013-07-31 Impact factor: 8.082
Authors: Luca A Lotta; Mark Wang; Jin Yu; Ida Martinelli; Fuli Yu; Serena M Passamonti; Dario Consonni; Emanuela Pappalardo; Marzia Menegatti; Steven E Scherer; Lora L Lewis; Humeira Akbar; Yuanqing Wu; Matthew N Bainbridge; Donna M Muzny; Pier M Mannucci; Richard A Gibbs; Flora Peyvandi Journal: BMC Med Genomics Date: 2012-02-21 Impact factor: 3.063
Authors: Scott M Stevens; Scott C Woller; Kenneth A Bauer; Raj Kasthuri; Mary Cushman; Michael Streiff; Wendy Lim; James D Douketis Journal: J Thromb Thrombolysis Date: 2016-01 Impact factor: 2.300