Literature DB >> 210404

High affinity of carozolol for beta-adrenoceptors coupled to the adenylyl cyclase in ventricular myocardium of kitten and Xenopus laevis.

T H Morris, L Birnbaumer, A J Kaumann.   

Abstract

Catecholamine-induced stimulation of adenylyl cyclase in ventricular membranes of kitten and Xenopus laevis was antagonized competitively by carazolol. Apparent equilibrium constants ranging between 100-170 pM were estimated for the beta-adrenoceptor-carazolol complex.

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Year:  1978        PMID： 210404     DOI： 10.1007/bf00498057

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  5 in total

1.  Mechanism of the positive inotropic response to certain ganglionic stimulants.

Authors:  W C LEE; F E SHIDEMAN
Journal:  J Pharmacol Exp Ther       Date:  1959-07       Impact factor: 4.030

2.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

3.  A highly sensitive adenylate cyclase assay.

Authors:  Y Salomon; C Londos; M Rodbell
Journal:  Anal Biochem       Date:  1974-04       Impact factor: 3.365

4.  Studies on receptor-mediated activation of adenylyl cyclases. IV. Characteristics of the adrenergic receptor coupled to myocardial adenylyl cyclase: stereospecificity for ligands and determination of apparent affinity constants for beta-blockers.

Authors:  A J Kaumann; L Birnbaumer
Journal:  J Biol Chem       Date:  1974-12-25       Impact factor: 5.157

5.  Some quantitative uses of drug antagonists.

Authors:  O ARUNLAKSHANA; H O SCHILD
Journal:  Br J Pharmacol Chemother       Date:  1959-03
  5 in total
  4 in total

1.  A comparison of the influence of N-isopropyl and N-tert butyl substituents on the affinity of ligands for sinoatrial beta-adrenoceptors in rat atria and beta-adrenoceptors coupled to the adenylyl cyclase in kitten ventricle.

Authors:  A J Kaumann; T H Morris; L Birnbaumer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-05       Impact factor: 3.000

2.  The effect of carazolol on the cardiovascular responses to adrenaline in stress sensitive pigs.

Authors:  N G Gregory; L J Wilkins
Journal:  Vet Res Commun       Date:  1982-05       Impact factor: 2.459

3.  Comparative assessment of beta-adrenoceptor blocking agents as simple competitive antagonists in isolated heart muscle: similarity of inotropic and chronotropic blocking potencies against isoproterenol.

Authors:  A J Kaumann; T K McInerny; D P Gilmour; J R Blinks
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-04       Impact factor: 3.000

4.  Recovery of beta-adrenoceptors and cyclic AMP response after long term treatment of intact heart cells with beta-blockers.

Authors:  C Becker; H Porzig
Journal:  Br J Pharmacol       Date:  1984-07       Impact factor: 8.739
  4 in total

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