| Literature DB >> 21037972 |
Shaun D Gittard1, Aleksandr Ovsianikov, Hasan Akar, Boris Chichkov, Nancy A Monteiro-Riviere, Shane Stafslien, Bret Chisholm, Chun-Che Shin, Chun-Ming Shih, Shing-Jong Lin, Yea-Yang Su, Roger J Narayan.
Abstract
The use of microneedles for transdermal drug delivery is limited due to the risk of infection associated with formation of channels through the stratum corneum layer of the epidermis. The risk of infection associated with use of microneedles may be reduced by imparting these devices with antimicrobial properties. In this study, a photopolymerization-micromolding technique was used to fabricate microneedle arrays from a photosensitive material containing polyethylene glycol 600 diacrylate, gentamicin sulfate, and a photoinitiator. Scanning electron microscopy indicated that the photopolymerization-micromolding process produced microneedle arrays that exhibited good microneedle-to-microneedle uniformity. An agar plating assay revealed that microneedles fabricated with polyethylene glycol 600 diacrylate containing 2 mg mL(-1) gentamicin sulfate inhibited growth of Staphylococcus aureus bacteria. Scanning electron microscopy revealed no platelet aggregation on the surfaces of platelet rich plasma-exposed undoped polyethylene glycol 600 diacrylate microneedles and gentamicin-doped polyethylene glycol 600 diacrylate microneedles. These efforts will enable wider adoption of microneedles for transdermal delivery of pharmacologic agents.Entities:
Year: 2010 PMID： 21037972 PMCID： PMC2964836 DOI： 10.1002/adem.200980012
Source DB: PubMed Journal: Adv Eng Mater ISSN： 1438-1656 Impact factor: 3.862