Literature DB >> 21035728

The kalimantacin/batumin biosynthesis operon encodes a self-resistance isoform of the FabI bacterial target.

Wesley Mattheus1, Joleen Masschelein, Ling-Jie Gao, Piet Herdewijn, Bart Landuyt, Guido Volckaert, Rob Lavigne.   

Abstract

BatG is a trans-2-enoyl-ACP reductase, encoded in the kalimantacin/batumin (kal/bat) biosynthesis operon. It is not essential for the production of the kal/bat secondary metabolite. Instead, BatG is an isoform of FabI, conferring full resistance to target bacteria. It also complements FabI in its role in fatty acid biosynthesis. The identification of FabI as the antibacterial target is important to assess clinical potential of the kalimantacin/batumin antibiotics against Staphylococcus aureus.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 21035728     DOI： 10.1016/j.chembiol.2010.07.015

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  17 in total

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