Literature DB >> 21035724

Using surrogates to bypass missing catalytic components.

Hyunjun Park1, Michael G Thomas.   

Abstract

Bryostatin is a natural product that has many medically promising biological activities. Understanding how bryostatin is assembled by the producting symbiotic bacterium has been hampered by the limited availability of genetic information. In the new report, Buchholz et al. (2010) circumvented this issue by using surrogates to replace missing catalytic components.
Copyright © 2010 Elsevier Ltd. All rights reserved.

Entities:  

Year:  2010        PMID： 21035724      PMCID： PMC2987683          DOI： 10.1016/j.chembiol.2010.10.001

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  9 in total

Review 1.  Biosynthesis and attachment of novel bacterial polyketide synthase starter units.

Authors:  Bradley S Moore; Christian Hertweck
Journal:  Nat Prod Rep       Date:  2002-02       Impact factor: 13.423

2.  Polyketide β-branching in bryostatin biosynthesis: identification of surrogate acetyl-ACP donors for BryR, an HMG-ACP synthase.

Authors:  Tonia J Buchholz; Christopher M Rath; Nicole B Lopanik; Noah P Gardner; Kristina Håkansson; David H Sherman
Journal:  Chem Biol       Date:  2010-10-29

3.  A gene cluster encoding rhizoxin biosynthesis in "Burkholderia rhizoxina", the bacterial endosymbiont of the fungus Rhizopus microsporus.

Authors:  Laila P Partida-Martinez; Christian Hertweck
Journal:  Chembiochem       Date:  2007-01-02       Impact factor: 3.164

4.  Identification of the putative bryostatin polyketide synthase gene cluster from "Candidatus Endobugula sertula", the uncultivated microbial symbiont of the marine bryozoan Bugula neritina.

Authors:  Sebastian Sudek; Nicole B Lopanik; Laura E Waggoner; Mark Hildebrand; Christine Anderson; Haibin Liu; Amrish Patel; David H Sherman; Margo G Haygood
Journal:  J Nat Prod       Date:  2007-01       Impact factor: 4.050

Review 5.  Biosynthesis of polyketide synthase extender units.

Authors:  Yolande A Chan; Angela M Podevels; Brian M Kevany; Michael G Thomas
Journal:  Nat Prod Rep       Date:  2009-01       Impact factor: 13.423

Review 6.  Clinical status of anti-cancer agents derived from marine sources.

Authors:  Ram Singh; Mukul Sharma; Penny Joshi; Diwan S Rawat
Journal:  Anticancer Agents Med Chem       Date:  2008-08       Impact factor: 2.505

7.  A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Abeta-induced biomarker abnormality on cultured fibroblasts.

Authors:  Tapan K Khan; Thomas J Nelson; Vishal A Verma; Paul A Wender; Daniel L Alkon
Journal:  Neurobiol Dis       Date:  2009-02-20       Impact factor: 5.996

Review 8.  Isoprenoid-like alkylations in polyketide biosynthesis.

Authors:  Christopher T Calderone
Journal:  Nat Prod Rep       Date:  2008-06-18       Impact factor: 13.423

Review 9.  Efficacy of selected natural products as therapeutic agents against cancer.

Authors:  Sanjeev Banerjee; Zhiwei Wang; Mussop Mohammad; Fazlul H Sarkar; Ramzi M Mohammad
Journal:  J Nat Prod       Date:  2008-02-27       Impact factor: 4.050
  9 in total

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