OBJECTIVE: Newfoundland and Labrador (NL) has the highest incidence rate of both colorectal cancer (CRC) and smoking prevalence in Canada. The objective of this study was to examine if CRC is associated with smoking in this population. METHODS: Newly diagnosed cases identified between 1999 and 2003 were frequency-matched by 5-year age group and sex with controls selected from the residents of NL through random digit dialing. A total of 702 cases and 717 controls consented to participate in the study and completed a set of self-administered questionnaires. Measures of tobacco use included type of tobacco, age of initiation of smoking, years of smoking, years since started smoking, number of cigarettes smoked daily, pack years, and years since abstention from smoking. Odds ratios were estimated using multivariate logistic regression. RESULTS: In comparison with non-smokers, former and current smokers were at a significantly elevated risk of CRC with corresponding odds ratios of 1.36 and 1.96. The risk significantly increased with cigarette smoking years, the amount of cigarettes smoked daily, and cigarette pack years. The risk significantly decreased with years of abstention from smoking cigarettes. This association was stronger among drinkers and in men. In addition, this effect was observed to be slightly stronger for rectum than colon cancer. DISCUSSION: In summary, cigarette smoking increased the risk of CRC in the NL population. The risk of CRC associated with cigarette smoking varies by sex, drinking status, and site of CRC.
OBJECTIVE: Newfoundland and Labrador (NL) has the highest incidence rate of both colorectal cancer (CRC) and smoking prevalence in Canada. The objective of this study was to examine if CRC is associated with smoking in this population. METHODS: Newly diagnosed cases identified between 1999 and 2003 were frequency-matched by 5-year age group and sex with controls selected from the residents of NL through random digit dialing. A total of 702 cases and 717 controls consented to participate in the study and completed a set of self-administered questionnaires. Measures of tobacco use included type of tobacco, age of initiation of smoking, years of smoking, years since started smoking, number of cigarettes smoked daily, pack years, and years since abstention from smoking. Odds ratios were estimated using multivariate logistic regression. RESULTS: In comparison with non-smokers, former and current smokers were at a significantly elevated risk of CRC with corresponding odds ratios of 1.36 and 1.96. The risk significantly increased with cigarette smoking years, the amount of cigarettes smoked daily, and cigarette pack years. The risk significantly decreased with years of abstention from smoking cigarettes. This association was stronger among drinkers and in men. In addition, this effect was observed to be slightly stronger for rectum than colon cancer. DISCUSSION: In summary, cigarette smoking increased the risk of CRC in the NL population. The risk of CRC associated with cigarette smoking varies by sex, drinking status, and site of CRC.
Authors: Kirsten M Donato; Katelyn Moore; Wendy M Parker; Susan K Peterson; Ellen R Gritz; Christopher I Amos; Karen H Lu; Patrick M Lynch; Miguel A Rodriguez-Bigas; Y Nancy You; Allison M Burton-Chase Journal: J Community Genet Date: 2019-04-23
Authors: Yun Zhu; Peizhon Peter Wang; Jing Zhao; Roger Green; Zhuoyu Sun; Barbara Roebothan; Josh Squires; Sharon Buehler; Elizabeth Dicks; Jinhui Zhao; Michelle Cotterchio; Peter T Campbell; Meera Jain; Patrick S Parfrey; John R Mclaughlin Journal: Br J Nutr Date: 2013-10-25 Impact factor: 3.718
Authors: Jinhui Zhao; Yun Zhu; Peizhong Peter Wang; Roy West; Sharon Buehler; Zhuoyu Sun; Josh Squires; Barbara Roebothan; John R McLaughlin; Peter T Campbell; Patrick S Parfrey Journal: BMC Public Health Date: 2012-02-01 Impact factor: 3.295
Authors: Zhuoyu Sun; Lin Liu; Peizhong Peter Wang; Barbara Roebothan; Jin Zhao; Elizabeth Dicks; Michelle Cotterchio; Sharon Buehler; Peter T Campbell; John R McLaughlin; Patrick S Parfrey Journal: Nutr J Date: 2012-03-26 Impact factor: 3.271
Authors: Susan Hurley; Debbie Goldberg; David O Nelson; Yani Lu; Katherine Henderson; Leslie Bernstein; Peggy Reynolds Journal: Cancer Causes Control Date: 2013-04-10 Impact factor: 2.532