Jianni Cong1, Ge Li, Dan Zhou, Yang Tao, Yu Xiong. 1. Institute of public health, Chongqing University of Medical Sciences, Chongqing 400016, China. congjianni@sina.co
Abstract
OBJECTIVE: To investigate the association of Sp110 gene SNP with tuberculosis occurrence of Chongqing Han people. METHODS: Design Use the case-control study design, and collect risk factors of tuberculosis by questionnaires. Use multiple methods to detect rs1135791C/T, rs722555A/G, 5'-UTR rs11679983A/G, rs28930679C/T, rs9061A/G, rs1063154G/T, rs1047254A/G, rs3948464C/T points SNP polymorphism. Use SAS software to perform significance test. And use MDR software to analyze the cross action of SNP points related to tuberculosis susceptibility. RESULTS: (1) the frequencies of Sp110 gene rs1135791CT genotype, rs722555 GG genotype, rs11679983 GG genotype, rs3948464CC genotype in the case group are significantly higher than those in the control group. (2) Logistic regression analyzes rs1135791C/T, rs722555A/G, rs11679983A/G, rs3948464C/T, smoking history, family with TB, per capita living space and BMI were with relation to tuberculosis. (3) Sp110 gene rs722555A/G has the cross action with 3 points: rs1135791C/T, rs11679983A/G and rs3948464C/T, respectively. CONCLUSION: rs1135791C/T, rs722555 A/G, rs11679983A/G, rs3948464C/T may be the risk factors for susceptibility to tuberculosis in Chongqing Han People.
OBJECTIVE: To investigate the association of Sp110 gene SNP with tuberculosis occurrence of Chongqing Han people. METHODS: Design Use the case-control study design, and collect risk factors of tuberculosis by questionnaires. Use multiple methods to detect rs1135791C/T, rs722555A/G, 5'-UTR rs11679983A/G, rs28930679C/T, rs9061A/G, rs1063154G/T, rs1047254A/G, rs3948464C/T points SNP polymorphism. Use SAS software to perform significance test. And use MDR software to analyze the cross action of SNP points related to tuberculosis susceptibility. RESULTS: (1) the frequencies of Sp110 gene rs1135791CT genotype, rs722555 GG genotype, rs11679983 GG genotype, rs3948464CC genotype in the case group are significantly higher than those in the control group. (2) Logistic regression analyzes rs1135791C/T, rs722555A/G, rs11679983A/G, rs3948464C/T, smoking history, family with TB, per capita living space and BMI were with relation to tuberculosis. (3) Sp110 gene rs722555A/G has the cross action with 3 points: rs1135791C/T, rs11679983A/G and rs3948464C/T, respectively. CONCLUSION: rs1135791C/T, rs722555 A/G, rs11679983A/G, rs3948464C/T may be the risk factors for susceptibility to tuberculosis in Chongqing Han People.