Literature DB >> 21896006

Are mouse models of human mycobacterial diseases relevant? Genetics says: 'yes!'.

Alexander S Apt1.   

Abstract

Relevance and accuracy of experimental mouse models of tuberculosis (TB) are the subject of constant debate. This article briefly reviews genetic aspects of this problem and provides a few examples of mycobacterial diseases with similar or identical genetic control in mice and humans. The two species display more similarities than differences regarding both genetics of susceptibility/severity of mycobacterial diseases and the networks of protective and pathological immune reactions. In the opinion of the author, refined mouse models of mycobacterial diseases are extremely useful for modelling the corresponding human conditions, if genetic diversity is taken into account.
© 2011 The Author. Immunology © 2011 Blackwell Publishing Ltd.

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Year:  2011        PMID： 21896006      PMCID： PMC3194219          DOI： 10.1111/j.1365-2567.2011.03472.x

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  90 in total

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Authors:  A K Berning; E M Eicher; W E Paul; I Scher
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3.  DiGeorge syndrome: congenital thymic hypoplasia. Animal model: congenitally athymic (nude) mouse.

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4.  Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.

Authors:  Jason D Fontenot; Marc A Gavin; Alexander Y Rudensky
Journal:  Nat Immunol       Date:  2003-03-03       Impact factor: 25.606

5.  An essential role for Scurfin in CD4+CD25+ T regulatory cells.

Authors:  Roli Khattri; Tom Cox; Sue-Ann Yasayko; Fred Ramsdell
Journal:  Nat Immunol       Date:  2003-03-03       Impact factor: 25.606

6.  Association between tuberculosis and a polymorphic NFkappaB binding site in the interferon gamma gene.

Authors:  Manda Rossouw; Hendrik J Nel; Graham S Cooke; Paul D van Helden; Eileen G Hoal
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7.  The host resistance locus sst1 controls innate immunity to Listeria monocytogenes infection in immunodeficient mice.

Authors:  Victor Boyartchuk; Mauricio Rojas; Bo-Shiun Yan; Ousman Jobe; Nicholas Hurt; David M Dorfman; Darren E Higgins; William F Dietrich; Igor Kramnik
Journal:  J Immunol       Date:  2004-10-15       Impact factor: 5.422

8.  Susceptibility to tuberculosis: a locus on mouse chromosome 19 (Trl-4) regulates Mycobacterium tuberculosis replication in the lungs.

Authors:  Loukia-Maria Mitsos; Lon R Cardon; Lynn Ryan; Ronald LaCourse; Robert J North; Philippe Gros
Journal:  Proc Natl Acad Sci U S A       Date:  2003-05-09       Impact factor: 11.205

9.  Genetic control of myeloproliferation in BXH-2 mice.

Authors:  Karine Turcotte; Susan Gauthier; Loukia-Maria Mitsos; Chaim Shustik; Neal G Copeland; Nancy A Jenkins; Jean-Christophe Fournet; Paul Jolicoeur; Philippe Gros
Journal:  Blood       Date:  2003-11-20       Impact factor: 22.113

10.  Iron, manganese, and cobalt transport by Nramp1 (Slc11a1) and Nramp2 (Slc11a2) expressed at the plasma membrane.

Authors:  John R Forbes; Philippe Gros
Journal:  Blood       Date:  2003-05-15       Impact factor: 22.113
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  5 in total

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Journal:  PLoS One       Date:  2014-12-02       Impact factor: 3.240

Review 2.  Animals devoid of pulmonary system as infection models in the study of lung bacterial pathogens.

Authors:  Yamilé López Hernández; Daniel Yero; Juan M Pinos-Rodríguez; Isidre Gibert
Journal:  Front Microbiol       Date:  2015-02-04       Impact factor: 5.640

Review 3.  Certain Polymorphisms in SP110 Gene Confer Susceptibility to Tuberculosis: A Comprehensive Review and Updated Meta-Analysis.

Authors:  Shuai Zhang; Xue Bin Wang; Ya Di Han; Chen Wang; Ye Zhou; Fang Zheng
Journal:  Yonsei Med J       Date:  2017-01       Impact factor: 2.759

4.  The QTL within the H2 Complex Involved in the Control of Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1 Gene.

Authors:  Nadezhda Logunova; Maria Korotetskaya; Vladimir Polshakov; Alexander Apt
Journal:  PLoS Genet       Date:  2015-11-30       Impact factor: 5.917

5.  Mycobacterial receptor, Clec4d (CLECSF8, MCL), is coregulated with Mincle and upregulated on mouse myeloid cells following microbial challenge.

Authors:  Bernhard Kerscher; Gillian J Wilson; Delyth M Reid; Daiki Mori; Julie A Taylor; Gurdyal S Besra; Sho Yamasaki; Janet A Willment; Gordon D Brown
Journal:  Eur J Immunol       Date:  2015-12-08       Impact factor: 5.532
  5 in total

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