Literature DB >> 21030229

TAM receptor signaling and autoimmune disease.

Carla V Rothlin1, Greg Lemke.   

Abstract

The TAM receptor tyrosine kinases Tyro3, Axl, and Mer and their ligands Gas6 and Protein S are essential for the phagocytosis of apoptotic cells and membranes in the adult immune, nervous, and reproductive systems. Genetic studies indicate that this receptor-ligand system is central to apoptotic cell engulfment that is triggered by the 'eat-me' signal phosphatidylserine (PtdSer). At the same time, TAM signaling is normally activated by Toll-like receptor (TLR) and type I interferon signaling, as part of the innate inflammatory response in dendritic cells (DCs) and macrophages, where it inhibits this response. Deficiencies in TAM signaling result in human retinal dystrophies and may contribute to lupus and other human autoimmune diseases.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 21030229      PMCID： PMC2997887          DOI： 10.1016/j.coi.2010.10.001

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  65 in total

1.  Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family.

Authors:  Q Lu; G Lemke
Journal:  Science       Date:  2001-07-13       Impact factor: 47.728

2.  Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6.

Authors:  B C Varnum; C Young; G Elliott; A Garcia; T D Bartley; Y W Fridell; R W Hunt; G Trail; C Clogston; R J Toso
Journal:  Nature       Date:  1995-02-16       Impact factor: 49.962

3.  Homozygous deletion in the coding sequence of the c-mer gene in RCS rats unravels general mechanisms of physiological cell adhesion and apoptosis.

Authors:  E Nandrot; E M Dufour; A C Provost; M O Péquignot; S Bonnel; K Gogat; D Marchant; C Rouillac; B Sépulchre de Condé; M T Bihoreau; C Shaver; J L Dufier; C Marsac; M Lathrop; M Menasche; M M Abitbol
Journal:  Neurobiol Dis       Date:  2000-12       Impact factor: 5.996

4.  Prevalence of anti-protein S antibodies in patients with systemic lupus erythematosus.

Authors:  K S Song; Y S Park; H K Kim
Journal:  Arthritis Rheum       Date:  2000-03

5.  Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa.

Authors:  A Gal; Y Li; D A Thompson; J Weir; U Orth; S G Jacobson; E Apfelstedt-Sylla; D Vollrath
Journal:  Nat Genet       Date:  2000-11       Impact factor: 38.330

6.  Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cells.

Authors:  Pradip Sen; Mark A Wallet; Zuoan Yi; Yingsu Huang; Michael Henderson; Clayton E Mathews; H Shelton Earp; Glenn Matsushima; Albert S Baldwin; Roland M Tisch
Journal:  Blood       Date:  2006-09-28       Impact factor: 22.113

7.  Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat.

Authors:  P M D'Cruz; D Yasumura; J Weir; M T Matthes; H Abderrahim; M M LaVail; D Vollrath
Journal:  Hum Mol Genet       Date:  2000-03-01       Impact factor: 6.150

8.  Phagocytosis and clearance of apoptotic cells is mediated by MER.

Authors:  R S Scott; E J McMahon; S M Pop; E A Reap; R Caricchio; P L Cohen; H S Earp; G K Matsushima
Journal:  Nature       Date:  2001-05-10       Impact factor: 49.962

9.  Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis.

Authors:  A Angelillo-Scherrer; P de Frutos; C Aparicio; E Melis; P Savi; F Lupu; J Arnout; M Dewerchin; M Hoylaerts; J Herbert; D Collen; B Dahlbäck; P Carmeliet
Journal:  Nat Med       Date:  2001-02       Impact factor: 53.440

10.  Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase.

Authors:  Philip L Cohen; Roberto Caricchio; Valsamma Abraham; Todd D Camenisch; J Charles Jennette; Robert A S Roubey; H Shelton Earp; Glenn Matsushima; Elizabeth A Reap
Journal:  J Exp Med       Date:  2002-07-01       Impact factor: 14.307
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  87 in total

Review 1.  Macrophage-tumor crosstalk: role of TAMR tyrosine kinase receptors and of their ligands.

Authors:  Thomas Schmidt; Isabel Ben-Batalla; Alexander Schultze; Sonja Loges
Journal:  Cell Mol Life Sci       Date:  2011-11-11       Impact factor: 9.261

2.  Immune modulation of vascular resident cells by Axl orchestrates carotid intima-media thickening.

Authors:  Janice Gerloff; Vyacheslav A Korshunov
Journal:  Am J Pathol       Date:  2012-05       Impact factor: 4.307

3.  Vitamin K deficiency leads to exacerbation of murine dextran sulfate sodium-induced colitis.

Authors:  Eri Shiraishi; Hideki Iijima; Shinichiro Shinzaki; Sachiko Nakajima; Takahiro Inoue; Satoshi Hiyama; Shoichiro Kawai; Manabu Araki; Toshio Yamaguchi; Yoshito Hayashi; Hironobu Fujii; Tsutomu Nishida; Masahiko Tsujii; Tetsuo Takehara
Journal:  J Gastroenterol       Date:  2015-08-28       Impact factor: 7.527

Review 4.  The role of TAM family receptors and ligands in the nervous system: From development to pathobiology.

Authors:  Bridget Shafit-Zagardo; Ross C Gruber; Juwen C DuBois
Journal:  Pharmacol Ther       Date:  2018-03-04       Impact factor: 12.310

5.  Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptors.

Authors:  Suchita Bhattacharyya; Anna Zagórska; Erin D Lew; Bimmi Shrestha; Carla V Rothlin; John Naughton; Michael S Diamond; Greg Lemke; John A T Young
Journal:  Cell Host Microbe       Date:  2013-08-14       Impact factor: 21.023

6.  Is the TAM receptor Axl a receptor for lymphocytic choriomeningitis virus?

Authors:  Brian M Sullivan; Megan J Welch; Greg Lemke; Michael B A Oldstone
Journal:  J Virol       Date:  2013-01-16       Impact factor: 5.103

7.  Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production.

Authors:  Robyn E Mills; Viola C Lam; Allison Tan; Nicole Cresalia; Nir Oksenberg; Julie Zikherman; Mark Anderson; Arthur Weiss; Michelle L Hermiston
Journal:  J Immunol       Date:  2015-03-13       Impact factor: 5.422

8.  Role of growth arrest-specific gene 6 in the development of fungal allergic airway disease in mice.

Authors:  Takehiko Shibata; Ugur Burcin Ismailoglu; Nicolai A Kittan; Ana Paula Moreira; Ana Lucia Coelho; Geoffrey L Chupp; Steven L Kunkel; Nicholas W Lukacs; Cory M Hogaboam
Journal:  Am J Respir Cell Mol Biol       Date:  2014-11       Impact factor: 6.914

9.  Opposing Roles of Tyrosine Kinase Receptors Mer and Axl Determine Clinical Outcomes in Experimental Immune-Mediated Nephritis.

Authors:  Yuxuan Zhen; Stephen O Priest; Wen-Hai Shao
Journal:  J Immunol       Date:  2016-08-15       Impact factor: 5.422

10.  Growth arrest-specific gene 6 (Gas6) levels are elevated in patients with chronic renal failure.

Authors:  Iris J Lee; Brendan Hilliard; Abhishek Swami; John C Madara; Swati Rao; Tapan Patel; John P Gaughan; Jean Lee; Crystal A Gadegbeku; Eric T Choi; Philip L Cohen
Journal:  Nephrol Dial Transplant       Date:  2012-08-20       Impact factor: 5.992
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