| Literature DB >> 23325690 |
Brian M Sullivan1, Megan J Welch, Greg Lemke, Michael B A Oldstone.
Abstract
A recent publication indicated that overexpression of Axl, a cellular receptor that negatively regulates Toll-like receptor signaling, enhanced the entry of viruses pseudotyped with the glycoprotein of lymphocytic choriomeningitis virus (LCMV) in vitro. In testing the biological relevance of these observations, we found differences in neither viral kinetics between LCMV infections of Axl(-/-) and wild-type mice nor T-cell responses prior to spontaneous viral clearance. Thus, Axl is not required for productive LCMV infection of mice.Entities:
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Year: 2013 PMID: 23325690 PMCID: PMC3624193 DOI: 10.1128/JVI.03268-12
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103