Literature DB >> 210173

Adenosine 3':5'-monophosphate receptor proteins in mammalian brain.

U Walter, P Kanof, H Schulman, P Greengard.   

Abstract

cAMP receptor proteins present in mammalian brain were identified and characterized with the use of the photoaffinity label 8-azido[32P]cAMP. Cytosol and membrane fractions from various regions of rat, guinea pig, and bovine brain contained two specific cAMP receptor proteins with apparent molecular weights of 47,000 and 52,000 to 55,000. Subcellular fractionation studies showed the highest amounts of these cAMP receptor proteins associated with cytosol fractions and synaptic membrane fractions. For both the cytosol and membrane fractions, the two cAMP receptor proteins represented almost all of the proteins specifically labeled by 8-azidol[32P]cAMP and appeared to be the regulatory subunits of cAMP-dependent protein kinases.

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Year:  1978        PMID： 210173

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  14 in total

1.  cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor.

Authors:  R E Rydel; L A Greene
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205

2.  Photoaffinity labelling of central-nervous-system myelin. Evidence for an endogenous type I cyclic AMP-dependent kinase phosphorylating the larger subunit of 2',3'-cyclic nucleotide 3'-phosphodiesterase.

Authors:  J M Bradbury; R J Thompson
Journal:  Biochem J       Date:  1984-07-15       Impact factor: 3.857

Review 3.  A-kinase anchoring proteins: a key to selective activation of cAMP-responsive events?

Authors:  V M Coghlan; S E Bergeson; L Langeberg; G Nilaver; J D Scott
Journal:  Mol Cell Biochem       Date:  1993-11       Impact factor: 3.396

4.  High-affinity binding of the regulatory subunit (RII) of cAMP-dependent protein kinase to microtubule-associated and other cellular proteins.

Authors:  S M Lohmann; P DeCamilli; I Einig; U Walter
Journal:  Proc Natl Acad Sci U S A       Date:  1984-11       Impact factor: 11.205

5.  Characterization of the protein kinase activities of human platelet supernatant and particulate fractions.

Authors:  S E Salama; R J Haslam
Journal:  Biochem J       Date:  1984-03-01       Impact factor: 3.857

6.  Transfection-mediated expression of a dominant cAMP-resistant phenotype in the opossum kidney (OK) cell line prevents parathyroid hormone-induced inhibition of Na-phosphate cotransport. A protein kinase-A-mediated event.

Authors:  J H Segal; A S Pollock
Journal:  J Clin Invest       Date:  1990-11       Impact factor: 14.808

7.  Frozen tissue sections as an experimental system to reveal specific binding sites for the regulatory subunit of type II cAMP-dependent protein kinase in neurons.

Authors:  P Miller; U Walter; W E Theurkauf; R B Vallee; P De Camilli
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

8.  On the disposition of a phosphorylated protein ("synapsin I") and its associated kinases in synaptosomes from rat brain.

Authors:  R Rodnight; H J Gower; R G Robertson
Journal:  Neurochem Res       Date:  1984-06       Impact factor: 3.996

9.  The amounts of rat liver cyclic AMP-dependent protein kinase I and II are differentially regulated by diet.

Authors:  R Ekanger; O K Vintermyr; S O Døskeland
Journal:  Biochem J       Date:  1988-12-01       Impact factor: 3.857

10.  Serotonin alters the subcellular distribution of a Ca2+/calmodulin-binding protein in neurons of Aplysia.

Authors:  T Saitoh; J H Schwartz
Journal:  Proc Natl Acad Sci U S A       Date:  1983-11       Impact factor: 11.205
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