Literature DB >> 2100246

Ramoplanin: a review of its discovery and its chemistry.

F Parenti1, R Ciabatti, B Cavalleri, J Kettenring.   

Abstract

Ramoplanin is a novel antibacterial agent with characteristics that make it suitable for development as a topical treatment for acne, infected wounds, and for treatment of antibiotic-associated diarrhoea. In this paper, the authors will review the discovery process and the descriptive chemistry of this novel molecular entity.

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Year:  1990        PMID： 2100246

Source DB:  PubMed          Journal:  Drugs Exp Clin Res        ISSN： 0378-6501


  8 in total

Review 1.  Recent advances in the chemistry and biology of naturally occurring antibiotics.

Authors:  K C Nicolaou; Jason S Chen; David J Edmonds; Anthony A Estrada
Journal:  Angew Chem Int Ed Engl       Date:  2009       Impact factor: 15.336

2.  A crystal structure of a dimer of the antibiotic ramoplanin illustrates membrane positioning and a potential Lipid II docking interface.

Authors:  James B Hamburger; Amanda J Hoertz; Amy Lee; Rachel J Senturia; Dewey G McCafferty; Patrick J Loll
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-03       Impact factor: 11.205

3.  The quest for supernatural products: the impact of total synthesis in complex natural products medicinal chemistry.

Authors:  Zhi-Chen Wu; Dale L Boger
Journal:  Nat Prod Rep       Date:  2020-11-10       Impact factor: 13.423

4.  Complexation of peptidoglycan intermediates by the lipoglycodepsipeptide antibiotic ramoplanin: minimal structural requirements for intermolecular complexation and fibril formation.

Authors:  Predrag Cudic; James K Kranz; Douglas C Behenna; Ryan G Kruger; Hellina Tadesse; A Joshua Wand; Yuri I Veklich; John W Weisel; Dewey G McCafferty
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-28       Impact factor: 11.205

5.  Alanine scan of [L-Dap(2)]ramoplanin A2 aglycon: assessment of the importance of each residue.

Authors:  Joonwoo Nam; Dongwoo Shin; Yosup Rew; Dale L Boger
Journal:  J Am Chem Soc       Date:  2007-06-26       Impact factor: 15.419

6.  Total synthesis and structure of the ramoplanin A1 and A3 aglycons: two minor components of the ramoplanin complex.

Authors:  Dongwoo Shin; Yosup Rew; Dale L Boger
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-02       Impact factor: 11.205

7.  Ramoplanin at bactericidal concentrations induces bacterial membrane depolarization in Staphylococcus aureus.

Authors:  Mu Cheng; Johnny X Huang; Soumya Ramu; Mark S Butler; Matthew A Cooper
Journal:  Antimicrob Agents Chemother       Date:  2014-09-02       Impact factor: 5.191

8.  The Difference a Single Atom Can Make: Synthesis and Design at the Chemistry-Biology Interface.

Authors:  Dale L Boger
Journal:  J Org Chem       Date:  2017-10-13       Impact factor: 4.354
  8 in total

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