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Literature DB >> 20980828

Reduction of Pten dose leads to neoplastic development in multiple organs of Pten (shRNA) mice.

Hong Shen-Li¹, Susan Koujak, Matthias Szablocs, Ramon Parsons.

Abstract

To address the impact of partial reduction of Pten on tumor initiation, we generated PtenshRNA mice, in which PTEN expression was reduced below normal levels in various tissues. PtenshRNA mice frequently developed lymphoid and prostatic hyperplasia, splenomegaly, and sebaceous adenomas. Our observations support the notion that partial reduction of the dose of Pten with shRNA is sufficient to induce neoplastic disease in multiple organ systems.

Entities: Chemical Disease Gene Species

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Year: 2010 PMID： 20980828 PMCID： PMC3018670 DOI： 10.4161/cbt.10.11.13814

Source DB: PubMed Journal: Cancer Biol Ther ISSN： 1538-4047 Impact factor: 4.742

33 in total

1. Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation.

Authors: Shunyou Wang; Alejandro J Garcia; Michelle Wu; Devon A Lawson; Owen N Witte; Hong Wu
Journal: Proc Natl Acad Sci U S A Date: 2006-01-23 Impact factor: 11.205

2. Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas.

Authors: K Inoue; F Zindy; D H Randle; J E Rehg; C J Sherr
Journal: Genes Dev Date: 2001-11-15 Impact factor: 11.361

3. The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice.

Authors: Mei-Ling Chen; Pei-Zhang Xu; Xiao-ding Peng; William S Chen; Grace Guzman; Ximing Yang; Antonio Di Cristofano; Pier Paolo Pandolfi; Nissim Hay
Journal: Genes Dev Date: 2006-06-15 Impact factor: 11.361

4. Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.

Authors: M Groszer; R Erickson; D D Scripture-Adams; R Lesche; A Trumpp; J A Zack; H I Kornblum; X Liu; H Wu
Journal: Science Date: 2001-11-01 Impact factor: 47.728

5. Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice.

Authors: Jose R Bayascas; Nick R Leslie; Ramon Parsons; Stewart Fleming; Dario R Alessi
Journal: Curr Biol Date: 2005-10-25 Impact factor: 10.834

Review 6. The Akt-mTOR tango and its relevance to cancer.

Authors: Nissim Hay
Journal: Cancer Cell Date: 2005-09 Impact factor: 31.743

7. Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis.

Authors: Minjung J Kim; Robert D Cardiff; Nishita Desai; Whitney A Banach-Petrosky; Ramon Parsons; Michael M Shen; Cory Abate-Shen
Journal: Proc Natl Acad Sci U S A Date: 2002-02-19 Impact factor: 11.205

8. Conditional deletion of Rb causes early stage prostate cancer.

Authors: Lisette A Maddison; Brent W Sutherland; Roberto J Barrios; Norman M Greenberg
Journal: Cancer Res Date: 2004-09-01 Impact factor: 12.701

9. Pten is essential for embryonic development and tumour suppression.

Authors: A Di Cristofano; B Pesce; C Cordon-Cardo; P P Pandolfi
Journal: Nat Genet Date: 1998-08 Impact factor: 38.330

10. Pten dose dictates cancer progression in the prostate.

Authors: Lloyd C Trotman; Masaru Niki; Zohar A Dotan; Jason A Koutcher; Antonio Di Cristofano; Andrew Xiao; Alan S Khoo; Pradip Roy-Burman; Norman M Greenberg; Terry Van Dyke; Carlos Cordon-Cardo; Pier Paolo Pandolfi
Journal: PLoS Biol Date: 2003-10-27 Impact factor: 8.029

15 in total

Reduction of Pten dose leads to neoplastic development in multiple organs of Pten (shRNA) mice.

1. Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation.

2. Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas.

3. The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice.

4. Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.

5. Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice.

Review 6. The Akt-mTOR tango and its relevance to cancer.

7. Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis.

8. Conditional deletion of Rb causes early stage prostate cancer.

9. Pten is essential for embryonic development and tumour suppression.

10. Pten dose dictates cancer progression in the prostate.

Review 1. Genetic alterations of PTEN in human melanoma.

2. PTEN regulates PLK1 and controls chromosomal stability during cell division.

Review 3. PTEN function: the long and the short of it.

4. Papillary renal cell carcinoma is associated with PTEN hamartoma tumor syndrome.

Review 5. PTEN level in tumor suppression: how much is too little?

6. Embryonic Barcoding of Equipotent Mammary Progenitors Functionally Identifies Breast Cancer Drivers.

Review 7. PTEN loss in the continuum of common cancers, rare syndromes and mouse models.

Review 8. PTEN in Hereditary and Sporadic Cancer.

9. Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer.

10. Model-based optimization of combination protocols for irradiation-insensitive cancers.