| Literature DB >> 20973474 |
Tomohiro Tanaka1, Wataru Nomura, Tetsuo Narumi, Akemi Masuda, Hirokazu Tamamura.
Abstract
To date, challenges in the design of bivalent ligands for G protein-coupled receptors (GPCRs) have revealed difficulties stemming from lack of knowledge of the state of oligomerization of the GPCR. The synthetic bivalent ligands with rigid linkers that are presented here can predict the dimer form of CXCR4 and be applied to molecular probes in cancerous cells. This "molecular ruler" approach would be useful in elucidating the details of CXCR4 oligomer formation.Entities:
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Year: 2010 PMID： 20973474 DOI： 10.1021/ja107447w
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419