Literature DB >> 20971038

Sirtuin-1 regulation of mammalian metabolism.

Matthew P Gillum1, Derek M Erion, Gerald I Shulman.   

Abstract

Sirtuin-1 (SirT1) is a nutrient-sensing deacetylase whose levels and activity increase with caloric restriction to preserve euglycemia and promote efficient energy utilization. Focusing on data obtained in vivo, we review how SirT1 orchestrates the adaptive response to fasting by stimulating hepatic gluconeogenesis and fatty acid oxidation, increasing circulating adiponectin levels and limiting immune activation. Finally, we consider its viability as a therapeutic target for the treatment of type 2 diabetes. Copyright Â
© 2010 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 20971038      PMCID： PMC3123438          DOI： 10.1016/j.molmed.2010.09.005

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  75 in total

1.  Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.

Authors:  Amy K Walker; Fajun Yang; Karen Jiang; Jun-Yuan Ji; Jennifer L Watts; Aparna Purushotham; Olivier Boss; Michael L Hirsch; Scott Ribich; Jesse J Smith; Kristine Israelian; Christoph H Westphal; Joseph T Rodgers; Toshi Shioda; Sarah L Elson; Peter Mulligan; Hani Najafi-Shoushtari; Josh C Black; Jitendra K Thakur; Lisa C Kadyk; Johnathan R Whetstine; Raul Mostoslavsky; Pere Puigserver; Xiaoling Li; Nicholas J Dyson; Anne C Hart; Anders M Näär
Journal:  Genes Dev       Date:  2010-07-01       Impact factor: 11.361

Review 2.  Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases.

Authors:  Shin-ichiro Imai; Leonard Guarente
Journal:  Trends Pharmacol Sci       Date:  2010-03-11       Impact factor: 14.819

3.  Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.

Authors:  S J Lin; P A Defossez; L Guarente
Journal:  Science       Date:  2000-09-22       Impact factor: 47.728

4.  Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation.

Authors:  Aparna Purushotham; Thaddeus T Schug; Qing Xu; Sailesh Surapureddi; Xiumei Guo; Xiaoling Li
Journal:  Cell Metab       Date:  2009-04       Impact factor: 27.287

5.  DBC1 is a negative regulator of SIRT1.

Authors:  Ja-Eun Kim; Junjie Chen; Zhenkun Lou
Journal:  Nature       Date:  2008-01-31       Impact factor: 49.962

6.  Resveratrol is not a direct activator of SIRT1 enzyme activity.

Authors:  Dirk Beher; John Wu; Suzanne Cumine; Ki Won Kim; Shu-Chen Lu; Larissa Atangan; Minghan Wang
Journal:  Chem Biol Drug Des       Date:  2009-10-20       Impact factor: 2.817

7.  Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity.

Authors:  Eun-Joo Kim; Jeong-Hoon Kho; Moo-Rim Kang; Soo-Jong Um
Journal:  Mol Cell       Date:  2007-10-26       Impact factor: 17.970

8.  The protein kinase IKKepsilon regulates energy balance in obese mice.

Authors:  Shian-Huey Chiang; Merlijn Bazuine; Carey N Lumeng; Lynn M Geletka; Jonathan Mowers; Nicole M White; Jing-Tyan Ma; Jie Zhou; Nathan Qi; Dan Westcott; Jennifer B Delproposto; Timothy S Blackwell; Fiona E Yull; Alan R Saltiel
Journal:  Cell       Date:  2009-09-04       Impact factor: 41.582

9.  Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.

Authors:  Jill C Milne; Philip D Lambert; Simon Schenk; David P Carney; Jesse J Smith; David J Gagne; Lei Jin; Olivier Boss; Robert B Perni; Chi B Vu; Jean E Bemis; Roger Xie; Jeremy S Disch; Pui Yee Ng; Joseph J Nunes; Amy V Lynch; Hongying Yang; Heidi Galonek; Kristine Israelian; Wendy Choy; Andre Iffland; Siva Lavu; Oliver Medvedik; David A Sinclair; Jerrold M Olefsky; Michael R Jirousek; Peter J Elliott; Christoph H Westphal
Journal:  Nature       Date:  2007-11-29       Impact factor: 49.962

10.  A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange.

Authors:  Yi Liu; Renaud Dentin; Danica Chen; Susan Hedrick; Kim Ravnskjaer; Simon Schenk; Jill Milne; David J Meyers; Phil Cole; John Yates; Jerrold Olefsky; Leonard Guarente; Marc Montminy
Journal:  Nature       Date:  2008-10-05       Impact factor: 49.962
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  42 in total

1.  Regulation of glycolytic enzyme phosphoglycerate mutase-1 by Sirt1 protein-mediated deacetylation.

Authors:  William C Hallows; Wei Yu; John M Denu
Journal:  J Biol Chem       Date:  2011-12-07       Impact factor: 5.157

2.  Vascular Smooth Muscle Sirtuin-1 Protects Against Diet-Induced Aortic Stiffness.

Authors:  Jessica L Fry; Leona Al Sayah; Robert M Weisbrod; Isabelle Van Roy; Xiang Weng; Richard A Cohen; Markus M Bachschmid; Francesca Seta
Journal:  Hypertension       Date:  2016-07-18       Impact factor: 10.190

3.  Accurate measurement of nicotinamide adenine dinucleotide (NAD⁺) with high-performance liquid chromatography.

Authors:  Jun Yoshino; Shin-Ichiro Imai
Journal:  Methods Mol Biol       Date:  2013

4.  Closer association of mitochondria with lipid droplets in hepatocytes and activation of Kupffer cells in resveratrol-treated senescence-accelerated mice.

Authors:  Motoko Shiozaki; Naoya Hayakawa; Masahiro Shibata; Masato Koike; Yasuo Uchiyama; Takahiro Gotow
Journal:  Histochem Cell Biol       Date:  2011-08-05       Impact factor: 4.304

5.  Prostaglandin E2 down-regulates sirtuin 1 (SIRT1), leading to elevated levels of aromatase, providing insights into the obesity-breast cancer connection.

Authors:  Kotha Subbaramaiah; Neil M Iyengar; Monica Morrow; Olivier Elemento; Xi Kathy Zhou; Andrew J Dannenberg
Journal:  J Biol Chem       Date:  2018-11-08       Impact factor: 5.157

6.  Lazy Updating of hubs can enable more realistic models by speeding up stochastic simulations.

Authors:  Kurt Ehlert; Laurence Loewe
Journal:  J Chem Phys       Date:  2014-11-28       Impact factor: 3.488

7.  Histone deacetylase sirtuin 1 deacetylates IRF1 protein and programs dendritic cells to control Th17 protein differentiation during autoimmune inflammation.

Authors:  Heeyoung Yang; Sang-Myeong Lee; Beixue Gao; Jinping Zhang; Deyu Fang
Journal:  J Biol Chem       Date:  2013-11-08       Impact factor: 5.157

Review 8.  Enzymatic and nonenzymatic protein acetylations control glycolysis process in liver diseases.

Authors:  Juan Li; Tongxin Wang; Jun Xia; Weilei Yao; Feiruo Huang
Journal:  FASEB J       Date:  2019-08-01       Impact factor: 5.191

9.  SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease.

Authors:  Jiyung Shin; Ming He; Yufei Liu; Silvana Paredes; Lidia Villanova; Katharine Brown; Xiaolei Qiu; Noushin Nabavi; Mary Mohrin; Kathleen Wojnoonski; Patrick Li; Hwei-Ling Cheng; Andrew J Murphy; David M Valenzuela; Hanzhi Luo; Pankaj Kapahi; Ronald Krauss; Raul Mostoslavsky; George D Yancopoulos; Frederick W Alt; Katrin F Chua; Danica Chen
Journal:  Cell Rep       Date:  2013-11-07       Impact factor: 9.423

10.  Major urinary protein 5, a scent communication protein, is regulated by dietary restriction and subsequent re-feeding in mice.

Authors:  K Giller; P Huebbe; F Doering; K Pallauf; G Rimbach
Journal:  Proc Biol Sci       Date:  2013-02-27       Impact factor: 5.349
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