| Literature DB >> 20969485 |
Ebe D'Adamo1, Cosimo Giannini, Valentina Chiavaroli, Tommaso de Giorgis, Alberto Verrotti, Francesco Chiarelli, Angelika Mohn.
Abstract
The endogenous secretory receptor for advanced glycation end products (esRAGE) and soluble RAGE (sRAGE) have been shown in human plasma and have emerged as reliable biomarkers of several pathological conditions, including insulin resistance and liver injury. We examined esRAGE and sRAGE levels in obese prepubertal children with and without liver steatosis. esRAGE and sRAGE levels were significantly lower in obese prepubertal children affected by liver steatosis and were independently related to liver steatosis. These findings suggest that AGE-RAGE pathway plays an independent role in the development of liver injury already present in this age group.Entities:
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Year: 2011 PMID: 20969485 DOI: 10.1089/ars.2010.3719
Source DB: PubMed Journal: Antioxid Redox Signal ISSN: 1523-0864 Impact factor: 8.401