BACKGROUND: Several factors contribute to the documented racial disparity in head and neck cancer, among which are socioeconomic status, access to care, and biologic factors. METHODS: Clinical characteristics of 87 African-American patients with head and neck cancer and a random sample of 261 white patients matched on age and smoking dose were associated with outcome. RESULTS: Black patients with cancers of the oral cavity and larynx were more likely diagnosed with advanced stages than whites, after adjusting for socioeconomic and insurance status and other confounding factors. There was a significant difference in relapse-free survival between blacks and whites with tumors of the larynx (hazard ratio [HR] = 3.36, 95% confidence interval [CI]: 1.62-7.00), but not with tumors of the oral cavity or pharynx. CONCLUSIONS: Differences in disease outcome may be attributed to a combination of tumor stage, socioeconomic status, and access to health care. The inclusion of biologic markers such as human papillomavirus (HPV) status is needed in future studies to further evaluate racial disparities in head and neck cancer outcomes.
BACKGROUND: Several factors contribute to the documented racial disparity in head and neck cancer, among which are socioeconomic status, access to care, and biologic factors. METHODS: Clinical characteristics of 87 African-American patients with head and neck cancer and a random sample of 261 white patients matched on age and smoking dose were associated with outcome. RESULTS: Black patients with cancers of the oral cavity and larynx were more likely diagnosed with advanced stages than whites, after adjusting for socioeconomic and insurance status and other confounding factors. There was a significant difference in relapse-free survival between blacks and whites with tumors of the larynx (hazard ratio [HR] = 3.36, 95% confidence interval [CI]: 1.62-7.00), but not with tumors of the oral cavity or pharynx. CONCLUSIONS: Differences in disease outcome may be attributed to a combination of tumor stage, socioeconomic status, and access to health care. The inclusion of biologic markers such as human papillomavirus (HPV) status is needed in future studies to further evaluate racial disparities in head and neck cancer outcomes.
Authors: Arun Sharma; Eduardo Méndez; Bevan Yueh; Pawadee Lohavanichbutr; John Houck; David R Doody; Neal D Futran; Melissa P Upton; Stephen M Schwartz; Chu Chen Journal: Otolaryngol Head Neck Surg Date: 2012-01-24 Impact factor: 3.497
Authors: Neil M Iyengar; Amit Kochhar; Patrick G Morris; Luc G Morris; Xi K Zhou; Ronald A Ghossein; Alejandro Pino; Matthew G Fury; David G Pfister; Snehal G Patel; Jay O Boyle; Clifford A Hudis; Andrew J Dannenberg Journal: Cancer Date: 2014-01-21 Impact factor: 6.860
Authors: Pamela D Thompson; Amos Sakwe; Rainelli Koumangoye; Wendell G Yarbrough; Josiah Ochieng; Dana R Marshall Journal: Exp Cell Res Date: 2013-12-12 Impact factor: 3.905
Authors: Andrew F Brouwer; Kevin He; Steven B Chinn; Alison M Mondul; Christina H Chapman; Marc D Ryser; Mousumi Banerjee; Marisa C Eisenberg; Rafael Meza; Jeremy M G Taylor Journal: Cancer Date: 2020-09-05 Impact factor: 6.860
Authors: Dan P Zandberg; Sandy Liu; Olga Goloubeva; Robert Ord; Scott E Strome; Mohan Suntharalingam; Rodney Taylor; Robert E Morales; Jeffrey S Wolf; Ann Zimrin; Joshua E Lubek; Lisa M Schumaker; Kevin J Cullen Journal: Head Neck Date: 2015-06-30 Impact factor: 3.147
Authors: Arjun K Parasher; Alan D Workman; Sarah M Kidwai; Erden Goljo; Anthony Del Signore; Alfred M Iloreta; Eric M Genden; Raj Shrivastava; Amol Navathe; Satish Govindaraj Journal: J Neurol Surg B Skull Base Date: 2018-03-21