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Literature DB >> 20965727

Engineered materials and the cellular microenvironment: a strengthening interface between cell biology and bioengineering.

Colin K Choi¹, Mark T Breckenridge, Christopher S Chen.

Abstract

Cells constantly probe and respond to a myriad of cues that are present in their local surroundings. The effects of soluble cues are relatively straightforward to manipulate, yet teasing apart how cells transduce signals from the extracellular matrix and neighboring cells has proven to be challenging due to the spatially and mechanically complex adhesive interactions. Over the years, advances in the engineering of biocompatible materials have enabled innovative ways to study adhesion-mediated cell functions, and numerous insights have elucidated the significance of the cellular microenvironment. Here, we highlight some of the major approaches and discuss the potential for future advancement.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
Biocompatible Materials

Year: 2010 PMID： 20965727 PMCID： PMC2991525 DOI： 10.1016/j.tcb.2010.09.007

Source DB: PubMed Journal: Trends Cell Biol ISSN： 0962-8924 Impact factor: 20.808

119 in total

1. Cell behaviour on micropatterned substrata: limits of extracellular matrix geometry for spreading and adhesion.

Authors: Dirk Lehnert; Bernhard Wehrle-Haller; Christian David; Ulrich Weiland; Christoph Ballestrem; Beat A Imhof; Martin Bastmeyer
Journal: J Cell Sci Date: 2004-01-01 Impact factor: 5.285

Review 2. Rho and Rac take center stage.

Authors: Keith Burridge; Krister Wennerberg
Journal: Cell Date: 2004-01-23 Impact factor: 41.582

3. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors.

Authors: A J Ridley; A Hall
Journal: Cell Date: 1992-08-07 Impact factor: 41.582

4. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling.

Authors: A J Ridley; H F Paterson; C L Johnston; D Diekmann; A Hall
Journal: Cell Date: 1992-08-07 Impact factor: 41.582

5. Taking cell-matrix adhesions to the third dimension.

Authors: E Cukierman; R Pankov; D R Stevens; K M Yamada
Journal: Science Date: 2001-11-23 Impact factor: 47.728

6. Transient frictional slip between integrin and the ECM in focal adhesions under myosin II tension.

Authors: Yvonne Aratyn-Schaus; Margaret L Gardel
Journal: Curr Biol Date: 2010-06-10 Impact factor: 10.834

7. Mechanical tugging force regulates the size of cell-cell junctions.

Authors: Zhijun Liu; John L Tan; Daniel M Cohen; Michael T Yang; Nathan J Sniadecki; Sami Alom Ruiz; Celeste M Nelson; Christopher S Chen
Journal: Proc Natl Acad Sci U S A Date: 2010-05-12 Impact factor: 11.205

Review 8. Designing materials to direct stem-cell fate.

Authors: Matthias P Lutolf; Penney M Gilbert; Helen M Blau
Journal: Nature Date: 2009-11-26 Impact factor: 49.962

9. Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics.

Authors: Carsten Grashoff; Brenton D Hoffman; Michael D Brenner; Ruobo Zhou; Maddy Parsons; Michael T Yang; Mark A McLean; Stephen G Sligar; Christopher S Chen; Taekjip Ha; Martin A Schwartz
Journal: Nature Date: 2010-07-08 Impact factor: 49.962

10. Regulation of protrusion, adhesion dynamics, and polarity by myosins IIA and IIB in migrating cells.

Authors: Miguel Vicente-Manzanares; Jessica Zareno; Leanna Whitmore; Colin K Choi; Alan F Horwitz
Journal: J Cell Biol Date: 2007-02-20 Impact factor: 10.539

15 in total

1. Cell culture on hydrophilicity-controlled silicon nitride surfaces.

Authors: Yuriko Masuda; Wataru Inami; Atsuo Miyakawa; Yoshimasa Kawata
Journal: World J Microbiol Biotechnol Date: 2015-09-28 Impact factor: 3.312

Review 2. Integrated micro/nanoengineered functional biomaterials for cell mechanics and mechanobiology: a materials perspective.

Authors: Yue Shao; Jianping Fu
Journal: Adv Mater Date: 2013-12-12 Impact factor: 30.849

Engineered materials and the cellular microenvironment: a strengthening interface between cell biology and bioengineering.

1. Cell behaviour on micropatterned substrata: limits of extracellular matrix geometry for spreading and adhesion.

Review 2. Rho and Rac take center stage.

3. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors.

4. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling.

5. Taking cell-matrix adhesions to the third dimension.

6. Transient frictional slip between integrin and the ECM in focal adhesions under myosin II tension.

7. Mechanical tugging force regulates the size of cell-cell junctions.

Review 8. Designing materials to direct stem-cell fate.

9. Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics.

10. Regulation of protrusion, adhesion dynamics, and polarity by myosins IIA and IIB in migrating cells.

1. Cell culture on hydrophilicity-controlled silicon nitride surfaces.

Review 2. Integrated micro/nanoengineered functional biomaterials for cell mechanics and mechanobiology: a materials perspective.

3. Fibroblast growth on micro- and nanopatterned surfaces prepared by a novel sol-gel phase separation method.

Review 4. Designing degradable hydrogels for orthogonal control of cell microenvironments.

Review 5. The present and future role of microfluidics in biomedical research.

Review 6. Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment.

7. The influence of scaffold material on chondrocytes under inflammatory conditions.

8. Biomimetic Surface Patterning Promotes Mesenchymal Stem Cell Differentiation.

9. Redirecting valvular myofibroblasts into dormant fibroblasts through light-mediated reduction in substrate modulus.

10. Microbead-based biomimetic synthetic neighbors enhance survival and function of rat pancreatic β-cells.