Literature DB >> 20965144

Troponin T isoforms and posttranscriptional modifications: Evolution, regulation and function.

Bin Wei1, J-P Jin.   

Abstract

Troponin-mediated Ca²(+)-regulation governs the actin-activated myosin motor function which powers striated (skeletal and cardiac) muscle contraction. This review focuses on the structure-function relationship of troponin T, one of the three protein subunits of the troponin complex. Molecular evolution, gene regulation, alternative RNA splicing, and posttranslational modifications of troponin T isoforms in skeletal and cardiac muscles are summarized with emphases on recent research progresses. The physiological and pathophysiological significances of the structural diversity and regulation of troponin T are discussed for impacts on striated muscle function and adaptation in health and diseases. Copyright Â
© 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20965144      PMCID： PMC3018564          DOI： 10.1016/j.abb.2010.10.013

Source DB:  PubMed          Journal:  Arch Biochem Biophys        ISSN： 0003-9861            Impact factor:   4.013


  141 in total

1.  Effects of removal and reconstitution of myosin regulatory light chain and troponin C on the Ca(2+)-sensitive ATPase activity of myofibrils from scallop striated muscle.

Authors:  F Shiraishi; S Morimoto; K Nishita; T Ojima; I Ohtsuki
Journal:  J Biochem       Date:  1999-12       Impact factor: 3.387

2.  The structure of the avian fast skeletal muscle troponin T gene: seven novel tandem-arranged exons in the exon x region.

Authors:  J Miyazaki; M Jozaki; N Nakatani; T Watanabe; R Saba; K Nakada; T Hirabayashi; I Yonemura
Journal:  J Muscle Res Cell Motil       Date:  1999-10       Impact factor: 2.698

Review 3.  Troponin I: inhibitor or facilitator.

Authors:  S V Perry
Journal:  Mol Cell Biochem       Date:  1999-01       Impact factor: 3.396

4.  Acidic and basic troponin T isoforms in mature fast-twitch skeletal muscle and effect on contractility.

Authors:  O Ogut; H Granzier; J P Jin
Journal:  Am J Physiol       Date:  1999-05

5.  Hypoxemia-induced modification of troponin I and T in canine diaphragm.

Authors:  J A Simpson; J E van Eyk; S Iscoe
Journal:  J Appl Physiol (1985)       Date:  2000-02

6.  Amino-acid sequence of tropomyosin-binding component of rabbit skeletal muscle troponin.

Authors:  J R Pearlstone; M R Carpenter; P Johnson; L B Smillie
Journal:  Proc Natl Acad Sci U S A       Date:  1976-06       Impact factor: 11.205

7.  Genomic sequence and structural organization of mouse slow skeletal muscle troponin T gene.

Authors:  Q Q Huang; A Chen; J P Jin
Journal:  Gene       Date:  1999-03-18       Impact factor: 3.688

8.  Ca2+ sensitization and potentiation of the maximum level of myofibrillar ATPase activity caused by mutations of troponin T found in familial hypertrophic cardiomyopathy.

Authors:  F Yanaga; S Morimoto; I Ohtsuki
Journal:  J Biol Chem       Date:  1999-03-26       Impact factor: 5.157

9.  The N-terminal region of troponin T is essential for the maximal activation of rat cardiac myofilaments.

Authors:  M Chandra; D E Montgomery; J J Kim; R J Solaro
Journal:  J Mol Cell Cardiol       Date:  1999-04       Impact factor: 5.000

10.  Fast skeletal muscle troponin T increases the cooperativity of transgenic mouse cardiac muscle contraction.

Authors:  Q Q Huang; F V Brozovich; J P Jin
Journal:  J Physiol       Date:  1999-10-01       Impact factor: 5.182
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  75 in total

1.  Phosphorylation, but not alternative splicing or proteolytic degradation, is conserved in human and mouse cardiac troponin T.

Authors:  Jiang Zhang; Han Zhang; Serife Ayaz-Guner; Yi-Chen Chen; Xintong Dong; Qingge Xu; Ying Ge
Journal:  Biochemistry       Date:  2011-06-15       Impact factor: 3.162

2.  The heart-specific NH2-terminal extension regulates the molecular conformation and function of cardiac troponin I.

Authors:  Shirin Akhter; Zhiling Zhang; J-P Jin
Journal:  Am J Physiol Heart Circ Physiol       Date:  2011-12-02       Impact factor: 4.733

3.  Toad heart utilizes exclusively slow skeletal muscle troponin T: an evolutionary adaptation with potential functional benefits.

Authors:  Han-Zhong Feng; Xuequn Chen; M Moazzem Hossain; Jian-Ping Jin
Journal:  J Biol Chem       Date:  2012-07-09       Impact factor: 5.157

4.  RNA-seq transcriptome analysis of extensor digitorum longus and soleus muscles in large white pigs.

Authors:  Jiayu Zhu; Xin'e Shi; Hongzhao Lu; Bo Xia; Yuefeng Li; Xiao Li; Qiangling Zhang; Gongshe Yang
Journal:  Mol Genet Genomics       Date:  2015-10-31       Impact factor: 3.291

5.  Chronic coexistence of two troponin T isoforms in adult transgenic mouse cardiomyocytes decreased contractile kinetics and caused dilatative remodeling.

Authors:  Zhi-Bin Yu; Hongguang Wei; J-P Jin
Journal:  Am J Physiol Cell Physiol       Date:  2012-04-25       Impact factor: 4.249

6.  Complex tropomyosin and troponin T isoform expression patterns in orbital and global fibers of adult dog and rat extraocular muscles.

Authors:  Sabahattin Bicer; Peter J Reiser
Journal:  J Muscle Res Cell Motil       Date:  2013-05-23       Impact factor: 2.698

7.  Functional significance of C-terminal mobile domain of cardiac troponin I.

Authors:  Nazanin Bohlooli Ghashghaee; Bertrand C W Tanner; Wen-Ji Dong
Journal:  Arch Biochem Biophys       Date:  2017-09-27       Impact factor: 4.013

8.  Isolation and characterization of three skeletal troponin genes and association with growth-related traits in Exopalaemon carinicauda.

Authors:  Jiajia Wang; Qianqian Ge; Jitao Li; Zhao Chen; Jian Li
Journal:  Mol Biol Rep       Date:  2018-12-01       Impact factor: 2.316

9.  Transcriptome analysis reveals that constant heat stress modifies the metabolism and structure of the porcine longissimus dorsi skeletal muscle.

Authors:  Yue Hao; Yuejin Feng; Peige Yang; Yanjun Cui; Jiru Liu; Chunhe Yang; Xianhong Gu
Journal:  Mol Genet Genomics       Date:  2016-08-25       Impact factor: 3.291

10.  In situ time-resolved FRET reveals effects of sarcomere length on cardiac thin-filament activation.

Authors:  King-Lun Li; Daniel Rieck; R John Solaro; Wenji Dong
Journal:  Biophys J       Date:  2014-08-05       Impact factor: 4.033
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