OBJECTIVES: to compare the efficacy of intravenous polymyxin B with other antimicrobials in the treatment of nosocomial Pseudomonas aeruginosa bacteraemia, assessing many potential confounding factors, including optimal dosage regimens of drugs. METHODS: a retrospective cohort study was performed. Patients ≥ 18 years of age and who received appropriate therapy for ≥ 48 h for P. aeruginosa bacteraemia were analysed. Clinical covariates were assessed and compared between patients treated with polymyxin B and other drugs (comparators). Data were retrieved from medical records. Renal toxicity was also assessed. A Cox regression model was performed including variables with a P ≤ 0.20 in the comparison between both groups. RESULTS: a total of 133 patients were included: 45 (33.8%) treated with polymyxin B and 88 (66.2%) with comparators. Most comparators (83.0%) were β-lactams. The overall in-hospital mortality was 41.4% (55/133): 66.7% (30/45) and 28.4% (25/88) in polymyxin B and comparator groups, respectively (P ≤ 0.001). The final multivariate model showed that treatment with polymyxin B was independently associated with in-hospital mortality (adjusted hazard ratio 1.91, 95% confidence interval 1.05-3.45), after adjustment for Pitt bacteraemia score, and the presence of mechanical ventilation and primary bloodstream infection. Patients treated with polymyxin B presented a higher rate of ≥ 100% increase in creatinine level from baseline than comparators [11/45 (24.4%) versus 4/88 (4.5%); P = 0.002], although this was not subjected to multivariate analysis. CONCLUSIONS: intravenous polymyxin B therapy was inferior to other drugs in the treatment of P. aeruginosa bacteraemia, as indicated by the higher rate of in-hospital mortality.
OBJECTIVES: to compare the efficacy of intravenous polymyxin B with other antimicrobials in the treatment of nosocomial Pseudomonas aeruginosa bacteraemia, assessing many potential confounding factors, including optimal dosage regimens of drugs. METHODS: a retrospective cohort study was performed. Patients ≥ 18 years of age and who received appropriate therapy for ≥ 48 h for P. aeruginosa bacteraemia were analysed. Clinical covariates were assessed and compared between patients treated with polymyxin B and other drugs (comparators). Data were retrieved from medical records. Renal toxicity was also assessed. A Cox regression model was performed including variables with a P ≤ 0.20 in the comparison between both groups. RESULTS: a total of 133 patients were included: 45 (33.8%) treated with polymyxin B and 88 (66.2%) with comparators. Most comparators (83.0%) were β-lactams. The overall in-hospital mortality was 41.4% (55/133): 66.7% (30/45) and 28.4% (25/88) in polymyxin B and comparator groups, respectively (P ≤ 0.001). The final multivariate model showed that treatment with polymyxin B was independently associated with in-hospital mortality (adjusted hazard ratio 1.91, 95% confidence interval 1.05-3.45), after adjustment for Pitt bacteraemia score, and the presence of mechanical ventilation and primary bloodstream infection. Patients treated with polymyxin B presented a higher rate of ≥ 100% increase in creatinine level from baseline than comparators [11/45 (24.4%) versus 4/88 (4.5%); P = 0.002], although this was not subjected to multivariate analysis. CONCLUSIONS: intravenous polymyxin B therapy was inferior to other drugs in the treatment of P. aeruginosa bacteraemia, as indicated by the higher rate of in-hospital mortality.
Authors: Josiane F John; Diego R Falci; Maria Helena Rigatto; Renata D Oliveira; Thaysa G Kremer; Alexandre P Zavascki Journal: Antimicrob Agents Chemother Date: 2017-12-21 Impact factor: 5.191
Authors: Mohammad A K Azad; Ben A Finnin; Anima Poudyal; Kathryn Davis; Jinhua Li; Prue A Hill; Roger L Nation; Tony Velkov; Jian Li Journal: Antimicrob Agents Chemother Date: 2013-06-24 Impact factor: 5.191
Authors: Maria Helena Rigatto; Maura S Oliveira; Lauro V Perdigão-Neto; Anna S Levin; Claudia M Carrilho; Marcos Toshiyuki Tanita; Felipe F Tuon; Douglas E Cardoso; Natane T Lopes; Diego R Falci; Alexandre P Zavascki Journal: Antimicrob Agents Chemother Date: 2016-03-25 Impact factor: 5.191
Authors: Pooja Manchandani; Jian Zhou; Kimberly R Ledesma; Luan D Truong; Diana S-L Chow; Jason L Eriksen; Vincent H Tam Journal: Antimicrob Agents Chemother Date: 2015-12-07 Impact factor: 5.191