OBJECTIVES: To study the effects of the combination of 670 nm and 810 nm diode lasers on diabetic wound healing parameters in rats. BACKGROUND: An alternative to traditional treatment modalities for diabetic ulcers is low-level laser therapy (LLLT). A number of published studies demonstrate the beneficial effects of LLLT, although several other studies also exist which indicate results to the contrary. METHODS: Four groups were present in our study: Diabetic-laser (n = 5), Diabetic-control (n = 4), Nondiabetic-laser (n = 5) and Nondiabetic-control (n = 5) groups. Two intervention (laser) groups underwent low level laser therapy using 670 nm diode laser (500 mW, 10 J, 48 s) in the wound context, and 810 nm diode laser (250 mW, 12 J, 50 s) to the wound margins. The wound area was measured using computer software after digital microscopic photography on days 0, 3, 6, 9, 12, 15, 20, and 24. RESULTS: There were no statistically significant differences between the diabetic and non-diabetic groups in the wound area, percentage of open wound area, and wound healing rate throughout the repeated measurements of the study. After seven days of low level laser therapy in the non-diabetic group, urine excretion was significantly increased in comparison with the control group. CONCLUSION: Overall, our study showed results of measured wound healing parameters that were not significantly different in the LLLT group compared with the control group. The urine volume increase in non-diabetic rats after LLLT was an incidental observation that warrants future study.
OBJECTIVES: To study the effects of the combination of 670 nm and 810 nm diode lasers on diabetic wound healing parameters in rats. BACKGROUND: An alternative to traditional treatment modalities for diabetic ulcers is low-level laser therapy (LLLT). A number of published studies demonstrate the beneficial effects of LLLT, although several other studies also exist which indicate results to the contrary. METHODS: Four groups were present in our study: Diabetic-laser (n = 5), Diabetic-control (n = 4), Nondiabetic-laser (n = 5) and Nondiabetic-control (n = 5) groups. Two intervention (laser) groups underwent low level laser therapy using 670 nm diode laser (500 mW, 10 J, 48 s) in the wound context, and 810 nm diode laser (250 mW, 12 J, 50 s) to the wound margins. The wound area was measured using computer software after digital microscopic photography on days 0, 3, 6, 9, 12, 15, 20, and 24. RESULTS: There were no statistically significant differences between the diabetic and non-diabetic groups in the wound area, percentage of open wound area, and wound healing rate throughout the repeated measurements of the study. After seven days of low level laser therapy in the non-diabetic group, urine excretion was significantly increased in comparison with the control group. CONCLUSION: Overall, our study showed results of measured wound healing parameters that were not significantly different in the LLLT group compared with the control group. The urine volume increase in non-diabeticrats after LLLT was an incidental observation that warrants future study.
Authors: Fernando José Camello de Lima; Olavo Barbosa de Oliveira Neto; Fabiano Timbó Barbosa; Ailton Mota do Nascimento Galvão; Fernando Wagner Silva Ramos; Christiane Calheiros Farias de Lima; Célio Fernando de Sousa Rodrigues Journal: Lasers Med Sci Date: 2016-02-09 Impact factor: 3.161
Authors: Andrezza Maria Côrtes Thomé Lima; Luiz Philippe da Silva Sergio; Adenilson de Souza da Fonseca Journal: Lasers Med Sci Date: 2019-09-16 Impact factor: 3.161