PURPOSE: Clinical translation of novel optical probes requires testing of human specimens ex vivo to ensure efficacy. However, it may be difficult to remove human tissue from the operating room due to regulatory/privacy issues. Therefore, we designed a portable fluorescence camera to test targeted optical imaging probes on human specimens in the operating room. PROCEDURES: A compact benchtop fluorescence camera was designed and built in-house. A mouse xenograft model of ovarian cancer with an activatable imaging probe based on rhodamine green was used to test the device. Comparison was made to commercially available imaging systems. RESULTS: The prototype camera produced images comparable to images acquired with commercially available, non-portable imaging systems. CONCLUSION: We demonstrate the feasibility of a specimen-based portable fluorescence camera for use in the operating room. Its small size ensures that tissue excised from patients can be tested promptly for fluorescence within the operating room environment, thus expediting the testing of novel imaging probes.
PURPOSE: Clinical translation of novel optical probes requires testing of human specimens ex vivo to ensure efficacy. However, it may be difficult to remove human tissue from the operating room due to regulatory/privacy issues. Therefore, we designed a portable fluorescence camera to test targeted optical imaging probes on human specimens in the operating room. PROCEDURES: A compact benchtop fluorescence camera was designed and built in-house. A mouse xenograft model of ovarian cancer with an activatable imaging probe based on rhodamine green was used to test the device. Comparison was made to commercially available imaging systems. RESULTS: The prototype camera produced images comparable to images acquired with commercially available, non-portable imaging systems. CONCLUSION: We demonstrate the feasibility of a specimen-based portable fluorescence camera for use in the operating room. Its small size ensures that tissue excised from patients can be tested promptly for fluorescence within the operating room environment, thus expediting the testing of novel imaging probes.
Authors: Summer L Gibbs-Strauss; Mireille Rosenberg; Barbara L Clough; Susan L Troyan; John V Frangioni Journal: Conf Proc IEEE Eng Med Biol Soc Date: 2009
Authors: Susan L Troyan; Vida Kianzad; Summer L Gibbs-Strauss; Sylvain Gioux; Aya Matsui; Rafiou Oketokoun; Long Ngo; Ali Khamene; Fred Azar; John V Frangioni Journal: Ann Surg Oncol Date: 2009-07-07 Impact factor: 5.344
Authors: Dan Gray; Evgenia Kim; Victoria Cotero; Paul Staudinger; Siavash Yazdanfar; Cristina Tan Hehir Journal: Proc SPIE Int Soc Opt Eng Date: 2012-02-03
Authors: Daniel C Gray; Evgenia M Kim; Victoria E Cotero; Anshika Bajaj; V Paul Staudinger; Cristina A Tan Hehir; Siavash Yazdanfar Journal: Biomed Opt Express Date: 2012-07-17 Impact factor: 3.732