Markus Schürks1, Pamela M Rist, Tobias Kurth. 1. Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215-1204, USA. mschuerks@rics.bwh.harvard.edu
Abstract
BACKGROUND AND METHODS: Data on the association between the SLC6A4 5-HTTLPR polymorphism and migraine are conflicting. We performed a systematic review and meta-analysis among studies published up to September 2009. For each study with genotype information, we calculated odds ratios (OR) and 95% confidence intervals (CI) assuming additive, dominant, and recessive genetic models. We then calculated pooled ORs and 95% CIs. RESULTS: Among the ten studies identified there was no overall association between the polymorphism and any migraine for Europeans or Asians. However, European women carrying the S allele had an increased risk for any migraine (dominant model: pooled OR=2.02; 95% CI 1.24-3.28). Results among Europeans further suggested an increased risk for migraine with aura among carriers of the S/S genotype (recessive model: pooled OR=1.41; 95% CI 0.83-2.40). CONCLUSIONS: While our results indicate no overall association between the SLC6A4 5-HTTLPR polymorphism and migraine among Europeans and Asians, gender and migraine aura status may have modifying roles among Europeans.
BACKGROUND AND METHODS: Data on the association between the SLC6A45-HTTLPR polymorphism and migraine are conflicting. We performed a systematic review and meta-analysis among studies published up to September 2009. For each study with genotype information, we calculated odds ratios (OR) and 95% confidence intervals (CI) assuming additive, dominant, and recessive genetic models. We then calculated pooled ORs and 95% CIs. RESULTS: Among the ten studies identified there was no overall association between the polymorphism and any migraine for Europeans or Asians. However, European women carrying the S allele had an increased risk for any migraine (dominant model: pooled OR=2.02; 95% CI 1.24-3.28). Results among Europeans further suggested an increased risk for migraine with aura among carriers of the S/S genotype (recessive model: pooled OR=1.41; 95% CI 0.83-2.40). CONCLUSIONS: While our results indicate no overall association between the SLC6A45-HTTLPR polymorphism and migraine among Europeans and Asians, gender and migraine aura status may have modifying roles among Europeans.
Authors: L Monari; M Mochi; M L Valentino; C Arnaldi; P Cortelli; A De Monte; G Pierangeli; G Prologo; C Scapoli; S Soriani; P Montagna Journal: Ital J Neurol Sci Date: 1997-10
Authors: A D Ogilvie; M B Russell; P Dhall; S Battersby; V Ulrich; C A Smith; G M Goodwin; A J Harmar; J Olesen Journal: Cephalalgia Date: 1998-01 Impact factor: 6.292
Authors: K P Lesch; D Bengel; A Heils; S Z Sabol; B D Greenberg; S Petri; J Benjamin; C R Müller; D H Hamer; D L Murphy Journal: Science Date: 1996-11-29 Impact factor: 47.728
Authors: Kaya K Jacobsen; Caroline M Nievergelt; Tetyana Zayats; Tiffany A Greenwood; Verneri Anttila; Hagop S Akiskal; Jan Haavik; Ole Bernt Fasmer; John R Kelsoe; Stefan Johansson; Ketil J Oedegaard Journal: J Affect Disord Date: 2014-10-12 Impact factor: 4.839