Literature DB >> 15642926

A functional serotonin transporter gene polymorphism is associated with migraine with aura.

M Marziniak1, R Mössner, A Schmitt, K P Lesch, C Sommer.   

Abstract

An association study was performed in 197 migraineurs with regard to a functional serotonin (5-HT) transporter (5-HTT) gene promoter polymorphism that leads to low or high 5-HT uptake activity. The frequency of the less active short allele was increased in migraineurs with aura but not in migraineurs without aura in comparison with the control population (p < 0.001). This indicates that the 5-HTT may be involved in the polygenic etiology of migraine with aura.

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Year:  2005        PMID： 15642926     DOI： 10.1212/01.WNL.0000148597.52312.9E

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


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